Genetic Determinants of Type 2 Diabetes Mellitus in Adults of African Ancestry: Identification of the Associated Factors

OBJECTIVES: H1: ADCYAP1R1, BDNF, CD36, HDAC4, NOS3, PON1, TCF7L2, TGFB1 were predominant in adults of African ancestry with or without T2DM. H2: There is a relationship between HBA1C, TG, LDL, FG, FI and genetic associations among adults of African ancestry and the following: H2a: ACGT risk alleles H2b: Chromosomal regions 2, 7, 10, 11, 19 H2c: Sequence variant impacts: intergenic, intron, missense, and synonymous H2d: Minor allele frequencies < .05 H2e: Lead reference SNPs H2f: Variant coordinates H3: ALDH1A1, B3GALT2, C8orf37, CASP16, CCSAP, CDKN2B, CHRNA5, CRNN, CYP7B1, FAT4, FOXP1, GPC6, GRM4, LMCD1, MMP19, MYOM2, NOL11, PHF8, RP11-180C1.1, SLC45A1, SLC9A8, TLE1, ZPLD1 were predominant in adults of African ancestry with peripheral vascular disease in T2DM. METHODS: Quantitative assessment of secondary data in the Type 2 Diabetes Knowledge Portal comprising nutritional phenotypic traits (peripheral vascular disease, hemoglobin A1C, triglycerides, low-density lipoprotein, fasting glucose, fasting insulin) and genetic associations risk allele, minor allele frequencies, reference single nucleotide polymorphisms, candidate genes, chromosomal regions, variant coordinates, and sequence variation impacts) related to Type 2 Diabetes Mellitus (T2DM) among adults of African ancestry with or without Type 2 Diabetes Mellitus to understand T2DM hereditary disease risk. RESULTS: H1 Results: χ2 (126, n = 5,877) = 1228.713, p < .001 H2a Results: χ2 (20, n = 62) = 43.052, p = .002 H2b Results: χ2 (20, n = 62) = 106.969, p < .001 H2c Results: χ2 (15, n = 62) = 60.470, p < .001 H2d Results: χ2 (228, n = 60) = 210.000, p = .798 H2e Results: χ2 (240, n = 61) = 269.118, p = .095 H2f Results: χ2 (245, n = 62) = 273.529, p = .102 H3 Results: χ2 (264, n = 23) = 276.000, p = .293 CONCLUSIONS: Hereditary disease risks for Type 2 Diabetes nutritional phenotypes and genetic associations are distinct in adults of African ancestry with or without Type 2 Diabetes Mellitus diagnosis. FUNDING SOURCES: Howard University.