Cargando…

Total n-6 Polyunsaturated Fatty Acid and Linoleic Acid Dietary Intakes Are Associated With Lower Serum Osteocalcin Among Postmenopausal Women

OBJECTIVES: Our research group has recently shown that plasma linoleic acid (LA), an essential n-6 polyunsaturated fatty acid (PUFA), was inversely associated with whole body bone mineral density (BMD) Z-score in a general US adult population. We aimed to determine whether dietary LA, arachidonic ac...

Descripción completa

Detalles Bibliográficos
Autores principales: Nesbeth, Paula-Dene, Weitzmann, M Neale, Roberts, David, Zreloff, Jennifer, Ivie, Elizabeth, Bergquist, Sharon, Alvarez, Jessica, Ziegler, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9193739/
http://dx.doi.org/10.1093/cdn/nzac057.019
_version_ 1784726539407982592
author Nesbeth, Paula-Dene
Weitzmann, M Neale
Roberts, David
Zreloff, Jennifer
Ivie, Elizabeth
Bergquist, Sharon
Alvarez, Jessica
Ziegler, Thomas
author_facet Nesbeth, Paula-Dene
Weitzmann, M Neale
Roberts, David
Zreloff, Jennifer
Ivie, Elizabeth
Bergquist, Sharon
Alvarez, Jessica
Ziegler, Thomas
author_sort Nesbeth, Paula-Dene
collection PubMed
description OBJECTIVES: Our research group has recently shown that plasma linoleic acid (LA), an essential n-6 polyunsaturated fatty acid (PUFA), was inversely associated with whole body bone mineral density (BMD) Z-score in a general US adult population. We aimed to determine whether dietary LA, arachidonic acid (AA) or total n-6 intake are likewise associated with serum bone turnover markers (BTMs) and BMD at sites prone to fracture, including total hip, lumbar spine, and femoral neck, among postmenopausal women without osteoporosis. METHODS: This was a cross-sectional study of healthy women (N = 34; 50–65 years) with onset of menopause < 5 years. Fasting serum samples were obtained, and BMD indexes were measured by dual X-ray absorptiometry (DXA) in the same visit. BMD values were converted to T-scores. Three-day food records were collected, and calorie-adjusted nutrient intakes calculated using Nutrition Data System for Research software. Serum concentrations of osteocalcin (OC, a bone formation biomarker) and C-terminal telopeptides of Type I collagen (CTX, a bone resorption biomarker) were measured by ELISA. Relationships between LA and each BMD T-score and serum BTM were assessed using linear regression adjusting for age, race, and body mass index. RESULTS: Total n-6 PUFA and LA intakes were not significantly associated with any BMD T-scores. AA intake was positively associated with lumbar spine BMD T-score [β = 10.4, (95% CI: 0.3, 20.5), P < 0.04]. For serum BTMs, total n-6 PUFA and LA intakes were inversely associated with serum osteocalcin [β = –6.8, 95% CI: (–13.2, –0.5) and β = –6.8, 95% CI: (–13.1, –0.5) respectively, both P < 0.05] but not significantly associated with serum CTX. AA intake was not significantly associated with either BTM. CONCLUSIONS: Dietary intake of total n-6 PUFAs and LA were inversely associated serum OC, while AA intake was positively associated with lumbar spine BMD. Cellular mechanistic and intervention studies in clinical populations are needed to confirm effects of total n-6 PUFA, LA, and AA intake on bone formation and BMD over time. FUNDING SOURCES: National Institutes of Health, John and Mary Brock Discovery Fund.
format Online
Article
Text
id pubmed-9193739
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-91937392022-06-14 Total n-6 Polyunsaturated Fatty Acid and Linoleic Acid Dietary Intakes Are Associated With Lower Serum Osteocalcin Among Postmenopausal Women Nesbeth, Paula-Dene Weitzmann, M Neale Roberts, David Zreloff, Jennifer Ivie, Elizabeth Bergquist, Sharon Alvarez, Jessica Ziegler, Thomas Curr Dev Nutr Energy and Macronutrient Metabolism OBJECTIVES: Our research group has recently shown that plasma linoleic acid (LA), an essential n-6 polyunsaturated fatty acid (PUFA), was inversely associated with whole body bone mineral density (BMD) Z-score in a general US adult population. We aimed to determine whether dietary LA, arachidonic acid (AA) or total n-6 intake are likewise associated with serum bone turnover markers (BTMs) and BMD at sites prone to fracture, including total hip, lumbar spine, and femoral neck, among postmenopausal women without osteoporosis. METHODS: This was a cross-sectional study of healthy women (N = 34; 50–65 years) with onset of menopause < 5 years. Fasting serum samples were obtained, and BMD indexes were measured by dual X-ray absorptiometry (DXA) in the same visit. BMD values were converted to T-scores. Three-day food records were collected, and calorie-adjusted nutrient intakes calculated using Nutrition Data System for Research software. Serum concentrations of osteocalcin (OC, a bone formation biomarker) and C-terminal telopeptides of Type I collagen (CTX, a bone resorption biomarker) were measured by ELISA. Relationships between LA and each BMD T-score and serum BTM were assessed using linear regression adjusting for age, race, and body mass index. RESULTS: Total n-6 PUFA and LA intakes were not significantly associated with any BMD T-scores. AA intake was positively associated with lumbar spine BMD T-score [β = 10.4, (95% CI: 0.3, 20.5), P < 0.04]. For serum BTMs, total n-6 PUFA and LA intakes were inversely associated with serum osteocalcin [β = –6.8, 95% CI: (–13.2, –0.5) and β = –6.8, 95% CI: (–13.1, –0.5) respectively, both P < 0.05] but not significantly associated with serum CTX. AA intake was not significantly associated with either BTM. CONCLUSIONS: Dietary intake of total n-6 PUFAs and LA were inversely associated serum OC, while AA intake was positively associated with lumbar spine BMD. Cellular mechanistic and intervention studies in clinical populations are needed to confirm effects of total n-6 PUFA, LA, and AA intake on bone formation and BMD over time. FUNDING SOURCES: National Institutes of Health, John and Mary Brock Discovery Fund. Oxford University Press 2022-06-14 /pmc/articles/PMC9193739/ http://dx.doi.org/10.1093/cdn/nzac057.019 Text en © The Author 2022. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Energy and Macronutrient Metabolism
Nesbeth, Paula-Dene
Weitzmann, M Neale
Roberts, David
Zreloff, Jennifer
Ivie, Elizabeth
Bergquist, Sharon
Alvarez, Jessica
Ziegler, Thomas
Total n-6 Polyunsaturated Fatty Acid and Linoleic Acid Dietary Intakes Are Associated With Lower Serum Osteocalcin Among Postmenopausal Women
title Total n-6 Polyunsaturated Fatty Acid and Linoleic Acid Dietary Intakes Are Associated With Lower Serum Osteocalcin Among Postmenopausal Women
title_full Total n-6 Polyunsaturated Fatty Acid and Linoleic Acid Dietary Intakes Are Associated With Lower Serum Osteocalcin Among Postmenopausal Women
title_fullStr Total n-6 Polyunsaturated Fatty Acid and Linoleic Acid Dietary Intakes Are Associated With Lower Serum Osteocalcin Among Postmenopausal Women
title_full_unstemmed Total n-6 Polyunsaturated Fatty Acid and Linoleic Acid Dietary Intakes Are Associated With Lower Serum Osteocalcin Among Postmenopausal Women
title_short Total n-6 Polyunsaturated Fatty Acid and Linoleic Acid Dietary Intakes Are Associated With Lower Serum Osteocalcin Among Postmenopausal Women
title_sort total n-6 polyunsaturated fatty acid and linoleic acid dietary intakes are associated with lower serum osteocalcin among postmenopausal women
topic Energy and Macronutrient Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9193739/
http://dx.doi.org/10.1093/cdn/nzac057.019
work_keys_str_mv AT nesbethpauladene totaln6polyunsaturatedfattyacidandlinoleicaciddietaryintakesareassociatedwithlowerserumosteocalcinamongpostmenopausalwomen
AT weitzmannmneale totaln6polyunsaturatedfattyacidandlinoleicaciddietaryintakesareassociatedwithlowerserumosteocalcinamongpostmenopausalwomen
AT robertsdavid totaln6polyunsaturatedfattyacidandlinoleicaciddietaryintakesareassociatedwithlowerserumosteocalcinamongpostmenopausalwomen
AT zreloffjennifer totaln6polyunsaturatedfattyacidandlinoleicaciddietaryintakesareassociatedwithlowerserumosteocalcinamongpostmenopausalwomen
AT ivieelizabeth totaln6polyunsaturatedfattyacidandlinoleicaciddietaryintakesareassociatedwithlowerserumosteocalcinamongpostmenopausalwomen
AT bergquistsharon totaln6polyunsaturatedfattyacidandlinoleicaciddietaryintakesareassociatedwithlowerserumosteocalcinamongpostmenopausalwomen
AT alvarezjessica totaln6polyunsaturatedfattyacidandlinoleicaciddietaryintakesareassociatedwithlowerserumosteocalcinamongpostmenopausalwomen
AT zieglerthomas totaln6polyunsaturatedfattyacidandlinoleicaciddietaryintakesareassociatedwithlowerserumosteocalcinamongpostmenopausalwomen