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Acid Lowering Agents and Trajectory of Vitamin B-12 Deficiency in the Boston Puerto Rican Health Study
OBJECTIVES: Studies have reported an association between acid lowering agents (ALAs) such as proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs) and malabsorption of vitamin B-12 (B-12). Therefore, we sought to examine the association between ALA use, including PPI and H2RA, a...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194025/ http://dx.doi.org/10.1093/cdn/nzac074.007 |
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author | Dinesh, Deepika Lee, Jong Soo Scott, Tammy Tucker, Katherine Palacios, Natalia |
author_facet | Dinesh, Deepika Lee, Jong Soo Scott, Tammy Tucker, Katherine Palacios, Natalia |
author_sort | Dinesh, Deepika |
collection | PubMed |
description | OBJECTIVES: Studies have reported an association between acid lowering agents (ALAs) such as proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs) and malabsorption of vitamin B-12 (B-12). Therefore, we sought to examine the association between ALA use, including PPI and H2RA, and B-12 deficiency in a cohort of older Puerto Rican adults residing in the Boston MA metropolitan area. METHODS: This analysis was conducted within the Boston Puerto Rican Health Study (BPRHS), an ongoing longitudinal cohort that enrolled 1502 self-identified Puerto Rican adults aged 45–75 y at baseline. Our study was comprised of 1428 participants at baseline, with complete baseline data on plasma B-12 concentration, of whom 1155 and 647 participated in wave-2 (mean 2.2 y from baseline ± 0.61 y), and wave-3 (mean 6.2 y ± 0.98 y), collections, respectively. B-12 deficiency was defined as plasma cobalamin <148 pmol/L or methyl malonic acid (MMA) >271 nmol/L. Covariate-adjusted logistic regression was used to examine the association between overall ALA, PPI and H2RA use and B-12 deficiency at baseline and wave-3 (mean 6.2 y) as well as between long-term use (mean 6.2 y) and B-12 deficiency at 6.2 y of follow-up. Logistic mixed effects models were used to examine associations between baseline ALA, PPI and H2RA use and trajectory of B-12 deficiency over 6.2 y of follow-up. Analyses were further stratified for B-12 supplement use, based on food frequency questionnaire. RESULTS: Of 1428 participants at baseline, 455 were ALA users, of which 361 were PPI, 112 H2RA and 18 concomitant users. In baseline cross-sectional analyses, including analyses stratified for B-12 supplement use, we did not observe an association between ALA, PPI, H2RA use and B-12 deficiency. We also did not observe an association between long-term ALA, PPI, H2RA use and B-12 deficiency at 6.2 y. Further, in trajectory analyses, we did not observe an association between baseline ALA, PPI, H2RA use and trajectory of B-12 deficiency from baseline through 6.2 y follow-up, including in analyses stratified for B-12 supplement use. CONCLUSIONS: In this study we did not observe an association between ALA, PPI, H2RA use and B-12 deficiency over wave-3 (6.2 y) follow-up. Larger studies with more detailed exposure information are needed to further examine these associations. FUNDING SOURCES: NIH. |
format | Online Article Text |
id | pubmed-9194025 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-91940252022-06-14 Acid Lowering Agents and Trajectory of Vitamin B-12 Deficiency in the Boston Puerto Rican Health Study Dinesh, Deepika Lee, Jong Soo Scott, Tammy Tucker, Katherine Palacios, Natalia Curr Dev Nutr Vitamins and Minerals OBJECTIVES: Studies have reported an association between acid lowering agents (ALAs) such as proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs) and malabsorption of vitamin B-12 (B-12). Therefore, we sought to examine the association between ALA use, including PPI and H2RA, and B-12 deficiency in a cohort of older Puerto Rican adults residing in the Boston MA metropolitan area. METHODS: This analysis was conducted within the Boston Puerto Rican Health Study (BPRHS), an ongoing longitudinal cohort that enrolled 1502 self-identified Puerto Rican adults aged 45–75 y at baseline. Our study was comprised of 1428 participants at baseline, with complete baseline data on plasma B-12 concentration, of whom 1155 and 647 participated in wave-2 (mean 2.2 y from baseline ± 0.61 y), and wave-3 (mean 6.2 y ± 0.98 y), collections, respectively. B-12 deficiency was defined as plasma cobalamin <148 pmol/L or methyl malonic acid (MMA) >271 nmol/L. Covariate-adjusted logistic regression was used to examine the association between overall ALA, PPI and H2RA use and B-12 deficiency at baseline and wave-3 (mean 6.2 y) as well as between long-term use (mean 6.2 y) and B-12 deficiency at 6.2 y of follow-up. Logistic mixed effects models were used to examine associations between baseline ALA, PPI and H2RA use and trajectory of B-12 deficiency over 6.2 y of follow-up. Analyses were further stratified for B-12 supplement use, based on food frequency questionnaire. RESULTS: Of 1428 participants at baseline, 455 were ALA users, of which 361 were PPI, 112 H2RA and 18 concomitant users. In baseline cross-sectional analyses, including analyses stratified for B-12 supplement use, we did not observe an association between ALA, PPI, H2RA use and B-12 deficiency. We also did not observe an association between long-term ALA, PPI, H2RA use and B-12 deficiency at 6.2 y. Further, in trajectory analyses, we did not observe an association between baseline ALA, PPI, H2RA use and trajectory of B-12 deficiency from baseline through 6.2 y follow-up, including in analyses stratified for B-12 supplement use. CONCLUSIONS: In this study we did not observe an association between ALA, PPI, H2RA use and B-12 deficiency over wave-3 (6.2 y) follow-up. Larger studies with more detailed exposure information are needed to further examine these associations. FUNDING SOURCES: NIH. Oxford University Press 2022-06-14 /pmc/articles/PMC9194025/ http://dx.doi.org/10.1093/cdn/nzac074.007 Text en © The Author 2022. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Vitamins and Minerals Dinesh, Deepika Lee, Jong Soo Scott, Tammy Tucker, Katherine Palacios, Natalia Acid Lowering Agents and Trajectory of Vitamin B-12 Deficiency in the Boston Puerto Rican Health Study |
title | Acid Lowering Agents and Trajectory of Vitamin B-12 Deficiency in the Boston Puerto Rican Health Study |
title_full | Acid Lowering Agents and Trajectory of Vitamin B-12 Deficiency in the Boston Puerto Rican Health Study |
title_fullStr | Acid Lowering Agents and Trajectory of Vitamin B-12 Deficiency in the Boston Puerto Rican Health Study |
title_full_unstemmed | Acid Lowering Agents and Trajectory of Vitamin B-12 Deficiency in the Boston Puerto Rican Health Study |
title_short | Acid Lowering Agents and Trajectory of Vitamin B-12 Deficiency in the Boston Puerto Rican Health Study |
title_sort | acid lowering agents and trajectory of vitamin b-12 deficiency in the boston puerto rican health study |
topic | Vitamins and Minerals |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194025/ http://dx.doi.org/10.1093/cdn/nzac074.007 |
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