cGAS and DDX41-STING mediated intrinsic immunity spreads intercellularly to promote neuroinflammation in SOD1 ALS model

Neuroinflammation exacerbates the progression of SOD1-driven amyotrophic lateral sclerosis (ALS), although the underlying mechanisms remain largely unknown. Herein, we demonstrate that misfolded SOD1 (SOD1(Mut))-causing ALS results in mitochondrial damage, thus triggering the release of mtDNA and an...

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Detalles Bibliográficos
Autores principales: Tan, Hong Yien, Yong, Yean Kong, Xue, Yuan Chao, Liu, Huitao, Furihata, Tomomi, Shankar, Esaki Muthu, Ng, Chen Seng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194172/
https://www.ncbi.nlm.nih.gov/pubmed/35712074
http://dx.doi.org/10.1016/j.isci.2022.104404

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