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Chronic Stress-Induced Depression and Anxiety Priming Modulated by Gut-Brain-Axis Immunity

OBJECTIVES: Chronic stress manifests as depressive- and anxiety-like behavior while recurrent stress elicits disproportionate psychiatric responses linked to stress-induced immunological priming. The gut-brain-microbiota-axis is a promising therapeutic target for stress-induced behavioral impairment...

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Autores principales: Pasinetti, Giulio, Westfall, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194303/
http://dx.doi.org/10.1093/cdn/nzac064.020
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author Pasinetti, Giulio
Westfall, Susan
author_facet Pasinetti, Giulio
Westfall, Susan
author_sort Pasinetti, Giulio
collection PubMed
description OBJECTIVES: Chronic stress manifests as depressive- and anxiety-like behavior while recurrent stress elicits disproportionate psychiatric responses linked to stress-induced immunological priming. The gut-brain-microbiota-axis is a promising therapeutic target for stress-induced behavioral impairments as it simultaneously modulates peripheral and brain immunological landscapes. METHODS: In this study, a combination of probiotics and prebiotics (i.e., synbiotic) promoted behavioral resilience to chronic and recurrent stress by normalizing gut microbiota populations and promoting regulatory T cell (Treg) expansion through modulation of ileal innate lymphoid cell (ILC)3 activity, an impact reflecting behavioral responses better than limbic brain region neuroinflammation. RESULTS: A multivariate machine learning model predicted a cross-tissue immunological signature of stress-induced behavioral impairment where ileal Treg/T helper17 cell ratio associated to hippocampal chemotactic chemokine and prefrontal cortex IL‐1 release in the context of stress-induced behavioral deficits. CONCLUSIONS: In conclusion, stress-induced behavioral impairments depend on the gut-brain microbiota-axis and through ileal immune regulation, synbiotics attenuate the associated depressive- and anxiety-like behavior. FUNDING SOURCES: The study was supported by grant number P50 AT008661-01 and U19 AT010835 from the NCCIH and the ODS.
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spelling pubmed-91943032022-06-14 Chronic Stress-Induced Depression and Anxiety Priming Modulated by Gut-Brain-Axis Immunity Pasinetti, Giulio Westfall, Susan Curr Dev Nutr Neuroscience/Nutrition and the Brain OBJECTIVES: Chronic stress manifests as depressive- and anxiety-like behavior while recurrent stress elicits disproportionate psychiatric responses linked to stress-induced immunological priming. The gut-brain-microbiota-axis is a promising therapeutic target for stress-induced behavioral impairments as it simultaneously modulates peripheral and brain immunological landscapes. METHODS: In this study, a combination of probiotics and prebiotics (i.e., synbiotic) promoted behavioral resilience to chronic and recurrent stress by normalizing gut microbiota populations and promoting regulatory T cell (Treg) expansion through modulation of ileal innate lymphoid cell (ILC)3 activity, an impact reflecting behavioral responses better than limbic brain region neuroinflammation. RESULTS: A multivariate machine learning model predicted a cross-tissue immunological signature of stress-induced behavioral impairment where ileal Treg/T helper17 cell ratio associated to hippocampal chemotactic chemokine and prefrontal cortex IL‐1 release in the context of stress-induced behavioral deficits. CONCLUSIONS: In conclusion, stress-induced behavioral impairments depend on the gut-brain microbiota-axis and through ileal immune regulation, synbiotics attenuate the associated depressive- and anxiety-like behavior. FUNDING SOURCES: The study was supported by grant number P50 AT008661-01 and U19 AT010835 from the NCCIH and the ODS. Oxford University Press 2022-06-14 /pmc/articles/PMC9194303/ http://dx.doi.org/10.1093/cdn/nzac064.020 Text en © The Author 2022. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Neuroscience/Nutrition and the Brain
Pasinetti, Giulio
Westfall, Susan
Chronic Stress-Induced Depression and Anxiety Priming Modulated by Gut-Brain-Axis Immunity
title Chronic Stress-Induced Depression and Anxiety Priming Modulated by Gut-Brain-Axis Immunity
title_full Chronic Stress-Induced Depression and Anxiety Priming Modulated by Gut-Brain-Axis Immunity
title_fullStr Chronic Stress-Induced Depression and Anxiety Priming Modulated by Gut-Brain-Axis Immunity
title_full_unstemmed Chronic Stress-Induced Depression and Anxiety Priming Modulated by Gut-Brain-Axis Immunity
title_short Chronic Stress-Induced Depression and Anxiety Priming Modulated by Gut-Brain-Axis Immunity
title_sort chronic stress-induced depression and anxiety priming modulated by gut-brain-axis immunity
topic Neuroscience/Nutrition and the Brain
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194303/
http://dx.doi.org/10.1093/cdn/nzac064.020
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