Evaluation of the Antioxidant Activity of Saponins Extracts in Marrubium vulgare L.

OBJECTIVES: This study is interested in the evaluation of the antioxidant activity of the saponins extracted from the Marrubium Vulgare L. METHODS: The saponins extracted were evaluated with three different methods: maceration after dilapidation D, soxhlet apparatus S and maceration E. The antioxidant activity was carried out with two methods: Ferric reducing antioxidant power FRAP and Phosphomolybdene PPM. RESULTS: The three methods present a yield of total saponins equal to 9.85%, 6.12% and 2.84% for the S extract, E extract and D extract, respectively. The FRAP test showed a significant antioxidant activity. Especially in the E extract which occupies the first place with a value of 2220.8 AAE/1g MS, in comparison with the ascorbic acid of 1000.2 AAE/1g DM for the concentration of 0.5mg/ml. The PPM test showed that all the saponins extracts present a higher activity than ascorbic acid, notably of the E extract which occupies the first place with a value of 15,808.8 AAE/1g DM, comparison with the ascorbic acid of 1288.5 AAE/1g DM for the concentration of 0.1mg/ml. CONCLUSIONS: This study showed the interest of the Marrubium vulgare L. as a potential source of new biologically natural substances. FUNDING SOURCES: Faculty of Medicine and Pharmacy & Faculty of Sciences and Technologies, University of Sidi Mohamed Ben Abdellah, Fez, Morocco.