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Dietary Fermented Red Ginseng Promotes Healthy Aging by Modulating Gut Microbiota Composition in Aged Mice

OBJECTIVES: Aging, a progressive decline of programmed cellular processes, is one of the common causes of dysbiosis leading to proinflammatory state in digestive tract. Fermented red ginseng (FRG) has immunomodulating effects which promote anti-aging, cancer prevention and metabolic disorders. Howev...

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Autores principales: Lee, Su-Jeong, Kim, Yoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194316/
http://dx.doi.org/10.1093/cdn/nzac069.023
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author Lee, Su-Jeong
Kim, Yoo
author_facet Lee, Su-Jeong
Kim, Yoo
author_sort Lee, Su-Jeong
collection PubMed
description OBJECTIVES: Aging, a progressive decline of programmed cellular processes, is one of the common causes of dysbiosis leading to proinflammatory state in digestive tract. Fermented red ginseng (FRG) has immunomodulating effects which promote anti-aging, cancer prevention and metabolic disorders. However, whether FRG supplementation facilitates healthy gut microbiota composition by influencing the gut microbiome profile is not fully elucidated. Thus, the goal of this study is to determine the effects of FRG on the gut microbiome composition between FRG-treated and non-treated young and old mice. METHODS: Young (11-week-old) and old (20-month-old) male C57BL/6J mice were treated water or FRG extract dissolved in water via oral gavage injection for 31 days (n = 10 per each group). We collected fecal samples before (day 0) and after (day 31) FRG administration and analyzed the microbiome profiles by 16s rRNA sequencing. To examine gut microbial community composition of each sample, we obtained Operational Taxonomic Units (OTUs) by clustering with 97% identity on the Effective Tags of all samples. RESULTS: Principal component analysis (PCA) revealed that FRG administration changed the gut microbiota composition gradually in old groups. It is shown that FRG diet restored the gut microbiome in old mice similar to young mice especially enriched Alistipes in genus level. This genus of bacteria is well-known as a protective role against liver and cardiovascular fibrotic disorder diseases. Also, FRG supplementation significantly increased Akkermansia in genus level and Verrucomicrobia in phylum level in old mice. It suggested that FRG supplementation might improve intestinal barrier function and modulate immune response. CONCLUSIONS: Collectively, our results indicate that FRG supplementation has a potential to exert healthy aging by influencing the gut microbiome composition. FUNDING SOURCES: This research is supported by start-up funding from the Vice President of Research's office at Oklahoma State University, and by the BTC Corporation.
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spelling pubmed-91943162022-06-14 Dietary Fermented Red Ginseng Promotes Healthy Aging by Modulating Gut Microbiota Composition in Aged Mice Lee, Su-Jeong Kim, Yoo Curr Dev Nutr Nutritional Microbiology/Microbiome OBJECTIVES: Aging, a progressive decline of programmed cellular processes, is one of the common causes of dysbiosis leading to proinflammatory state in digestive tract. Fermented red ginseng (FRG) has immunomodulating effects which promote anti-aging, cancer prevention and metabolic disorders. However, whether FRG supplementation facilitates healthy gut microbiota composition by influencing the gut microbiome profile is not fully elucidated. Thus, the goal of this study is to determine the effects of FRG on the gut microbiome composition between FRG-treated and non-treated young and old mice. METHODS: Young (11-week-old) and old (20-month-old) male C57BL/6J mice were treated water or FRG extract dissolved in water via oral gavage injection for 31 days (n = 10 per each group). We collected fecal samples before (day 0) and after (day 31) FRG administration and analyzed the microbiome profiles by 16s rRNA sequencing. To examine gut microbial community composition of each sample, we obtained Operational Taxonomic Units (OTUs) by clustering with 97% identity on the Effective Tags of all samples. RESULTS: Principal component analysis (PCA) revealed that FRG administration changed the gut microbiota composition gradually in old groups. It is shown that FRG diet restored the gut microbiome in old mice similar to young mice especially enriched Alistipes in genus level. This genus of bacteria is well-known as a protective role against liver and cardiovascular fibrotic disorder diseases. Also, FRG supplementation significantly increased Akkermansia in genus level and Verrucomicrobia in phylum level in old mice. It suggested that FRG supplementation might improve intestinal barrier function and modulate immune response. CONCLUSIONS: Collectively, our results indicate that FRG supplementation has a potential to exert healthy aging by influencing the gut microbiome composition. FUNDING SOURCES: This research is supported by start-up funding from the Vice President of Research's office at Oklahoma State University, and by the BTC Corporation. Oxford University Press 2022-06-14 /pmc/articles/PMC9194316/ http://dx.doi.org/10.1093/cdn/nzac069.023 Text en © The Author 2022. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Nutritional Microbiology/Microbiome
Lee, Su-Jeong
Kim, Yoo
Dietary Fermented Red Ginseng Promotes Healthy Aging by Modulating Gut Microbiota Composition in Aged Mice
title Dietary Fermented Red Ginseng Promotes Healthy Aging by Modulating Gut Microbiota Composition in Aged Mice
title_full Dietary Fermented Red Ginseng Promotes Healthy Aging by Modulating Gut Microbiota Composition in Aged Mice
title_fullStr Dietary Fermented Red Ginseng Promotes Healthy Aging by Modulating Gut Microbiota Composition in Aged Mice
title_full_unstemmed Dietary Fermented Red Ginseng Promotes Healthy Aging by Modulating Gut Microbiota Composition in Aged Mice
title_short Dietary Fermented Red Ginseng Promotes Healthy Aging by Modulating Gut Microbiota Composition in Aged Mice
title_sort dietary fermented red ginseng promotes healthy aging by modulating gut microbiota composition in aged mice
topic Nutritional Microbiology/Microbiome
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194316/
http://dx.doi.org/10.1093/cdn/nzac069.023
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