The role of Lrp6-mediated Wnt/β-catenin signaling in the development and intervention of spinal neural tube defects in mice

Neural tube defects (NTDs) are among the common and severe birth defects with poorly understood etiology. Mutations in the Wnt co-receptor LRP6 are associated with NTDs in humans. Either gain-of-function (GOF) or loss-of-function (LOF) mutations of Lrp6 can cause NTDs in mice. NTDs in Lrp6-GOF mutan...

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Detalles Bibliográficos
Autores principales: Zhao, Tianyu, McMahon, Moira, Reynolds, Kurt, Saha, Subbroto Kumar, Stokes, Arjun, Zhou, Chengji J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194482/
https://www.ncbi.nlm.nih.gov/pubmed/35514236
http://dx.doi.org/10.1242/dmm.049517

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