Data and experimental setup for a comprehensive study of ketamine's effect on neuronal plasticity following social isolation rearing in male and female rats

In this study, we collected electrophysiological data from acute hippocampal slices of male and female Sprague Dawley rats. Rats were exposed to social isolation rearing and then acutely treated with various doses of ketamine in order to rescue hippocampal plasticity deficits induced by isolation st...

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Autores principales: Guerrero, Alfonso Brea, Logue, Jordan, Schoepfer, Kristin, Zhou, Yi, Kabbaj, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Data Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194694/
https://www.ncbi.nlm.nih.gov/pubmed/35712367
http://dx.doi.org/10.1016/j.dib.2022.108338
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author Guerrero, Alfonso Brea
Logue, Jordan
Schoepfer, Kristin
Zhou, Yi
Kabbaj, Mohamed
author_facet Guerrero, Alfonso Brea
Logue, Jordan
Schoepfer, Kristin
Zhou, Yi
Kabbaj, Mohamed
author_sort Guerrero, Alfonso Brea
collection PubMed
description In this study, we collected electrophysiological data from acute hippocampal slices of male and female Sprague Dawley rats. Rats were exposed to social isolation rearing and then acutely treated with various doses of ketamine in order to rescue hippocampal plasticity deficits induced by isolation stress. We used two different approaches to study neuronal plasticity: Long-Term Potentiation (LTP) which is a well-established cellular model for memory and Paired-Pulse Facilitation (PPF) which is short-term of presynaptic plasticity. The aim of this article is to offer more experimental details about out LTP and PPF procedures.
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spelling pubmed-91946942022-06-15 Data and experimental setup for a comprehensive study of ketamine's effect on neuronal plasticity following social isolation rearing in male and female rats Guerrero, Alfonso Brea Logue, Jordan Schoepfer, Kristin Zhou, Yi Kabbaj, Mohamed Data Brief Data Article In this study, we collected electrophysiological data from acute hippocampal slices of male and female Sprague Dawley rats. Rats were exposed to social isolation rearing and then acutely treated with various doses of ketamine in order to rescue hippocampal plasticity deficits induced by isolation stress. We used two different approaches to study neuronal plasticity: Long-Term Potentiation (LTP) which is a well-established cellular model for memory and Paired-Pulse Facilitation (PPF) which is short-term of presynaptic plasticity. The aim of this article is to offer more experimental details about out LTP and PPF procedures. Elsevier 2022-06-01 /pmc/articles/PMC9194694/ /pubmed/35712367 http://dx.doi.org/10.1016/j.dib.2022.108338 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Data Article
Guerrero, Alfonso Brea
Logue, Jordan
Schoepfer, Kristin
Zhou, Yi
Kabbaj, Mohamed
Data and experimental setup for a comprehensive study of ketamine's effect on neuronal plasticity following social isolation rearing in male and female rats
title Data and experimental setup for a comprehensive study of ketamine's effect on neuronal plasticity following social isolation rearing in male and female rats
title_full Data and experimental setup for a comprehensive study of ketamine's effect on neuronal plasticity following social isolation rearing in male and female rats
title_fullStr Data and experimental setup for a comprehensive study of ketamine's effect on neuronal plasticity following social isolation rearing in male and female rats
title_full_unstemmed Data and experimental setup for a comprehensive study of ketamine's effect on neuronal plasticity following social isolation rearing in male and female rats
title_short Data and experimental setup for a comprehensive study of ketamine's effect on neuronal plasticity following social isolation rearing in male and female rats
title_sort data and experimental setup for a comprehensive study of ketamine's effect on neuronal plasticity following social isolation rearing in male and female rats
topic Data Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194694/
https://www.ncbi.nlm.nih.gov/pubmed/35712367
http://dx.doi.org/10.1016/j.dib.2022.108338
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