Safety and Efficacy of Semorinemab in Individuals With Prodromal to Mild Alzheimer Disease: A Randomized Clinical Trial

IMPORTANCE: Neurofibrillary tangles composed of aggregated tau protein are one of the neuropathological hallmarks of Alzheimer disease (AD) and correlate with clinical disease severity. Monoclonal antibodies targeting tau may have the potential to ameliorate AD progression by slowing or stopping the...

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Detalles Bibliográficos
Autores principales: Teng, Edmond, Manser, Paul T., Pickthorn, Karen, Brunstein, Flavia, Blendstrup, Mira, Sanabria Bohorquez, Sandra, Wildsmith, Kristin R., Toth, Bali, Dolton, Michael, Ramakrishnan, Vidya, Bobbala, Ashwini, Sikkes, Sietske A. M., Ward, Michael, Fuji, Reina N., Kerchner, Geoffrey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2022
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194753/
https://www.ncbi.nlm.nih.gov/pubmed/35696185
http://dx.doi.org/10.1001/jamaneurol.2022.1375

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