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Progress of Nanomaterials in Photodynamic Therapy Against Tumor

Photodynamic therapy (PDT) is an advanced therapeutic strategy with light-triggered, minimally invasive, high spatiotemporal selective and low systemic toxicity properties, which has been widely used in the clinical treatment of many solid tumors in recent years. Any strategies that improve the thre...

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Autores principales: Chen, Lei, Huang, Jiahui, Li, Xiaotong, Huang, Miaoting, Zeng, Shaoting, Zheng, Jiayi, Peng, Shuyi, Li, Shiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194820/
https://www.ncbi.nlm.nih.gov/pubmed/35711646
http://dx.doi.org/10.3389/fbioe.2022.920162
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author Chen, Lei
Huang, Jiahui
Li, Xiaotong
Huang, Miaoting
Zeng, Shaoting
Zheng, Jiayi
Peng, Shuyi
Li, Shiying
author_facet Chen, Lei
Huang, Jiahui
Li, Xiaotong
Huang, Miaoting
Zeng, Shaoting
Zheng, Jiayi
Peng, Shuyi
Li, Shiying
author_sort Chen, Lei
collection PubMed
description Photodynamic therapy (PDT) is an advanced therapeutic strategy with light-triggered, minimally invasive, high spatiotemporal selective and low systemic toxicity properties, which has been widely used in the clinical treatment of many solid tumors in recent years. Any strategies that improve the three elements of PDT (light, oxygen, and photosensitizers) can improve the efficacy of PDT. However, traditional PDT is confronted some challenges of poor solubility of photosensitizers and tumor suppressive microenvironment. To overcome the related obstacles of PDT, various strategies have been investigated in terms of improving photosensitizers (PSs) delivery, penetration of excitation light sources, and hypoxic tumor microenvironment. In addition, compared with a single treatment mode, the synergistic treatment of multiple treatment modalities such as photothermal therapy, chemotherapy, and radiation therapy can improve the efficacy of PDT. This review summarizes recent advances in nanomaterials, including metal nanoparticles, liposomes, hydrogels and polymers, to enhance the efficiency of PDT against malignant tumor.
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spelling pubmed-91948202022-06-15 Progress of Nanomaterials in Photodynamic Therapy Against Tumor Chen, Lei Huang, Jiahui Li, Xiaotong Huang, Miaoting Zeng, Shaoting Zheng, Jiayi Peng, Shuyi Li, Shiying Front Bioeng Biotechnol Bioengineering and Biotechnology Photodynamic therapy (PDT) is an advanced therapeutic strategy with light-triggered, minimally invasive, high spatiotemporal selective and low systemic toxicity properties, which has been widely used in the clinical treatment of many solid tumors in recent years. Any strategies that improve the three elements of PDT (light, oxygen, and photosensitizers) can improve the efficacy of PDT. However, traditional PDT is confronted some challenges of poor solubility of photosensitizers and tumor suppressive microenvironment. To overcome the related obstacles of PDT, various strategies have been investigated in terms of improving photosensitizers (PSs) delivery, penetration of excitation light sources, and hypoxic tumor microenvironment. In addition, compared with a single treatment mode, the synergistic treatment of multiple treatment modalities such as photothermal therapy, chemotherapy, and radiation therapy can improve the efficacy of PDT. This review summarizes recent advances in nanomaterials, including metal nanoparticles, liposomes, hydrogels and polymers, to enhance the efficiency of PDT against malignant tumor. Frontiers Media S.A. 2022-05-31 /pmc/articles/PMC9194820/ /pubmed/35711646 http://dx.doi.org/10.3389/fbioe.2022.920162 Text en Copyright © 2022 Chen, Huang, Li, Huang, Zeng, Zheng, Peng and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Chen, Lei
Huang, Jiahui
Li, Xiaotong
Huang, Miaoting
Zeng, Shaoting
Zheng, Jiayi
Peng, Shuyi
Li, Shiying
Progress of Nanomaterials in Photodynamic Therapy Against Tumor
title Progress of Nanomaterials in Photodynamic Therapy Against Tumor
title_full Progress of Nanomaterials in Photodynamic Therapy Against Tumor
title_fullStr Progress of Nanomaterials in Photodynamic Therapy Against Tumor
title_full_unstemmed Progress of Nanomaterials in Photodynamic Therapy Against Tumor
title_short Progress of Nanomaterials in Photodynamic Therapy Against Tumor
title_sort progress of nanomaterials in photodynamic therapy against tumor
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194820/
https://www.ncbi.nlm.nih.gov/pubmed/35711646
http://dx.doi.org/10.3389/fbioe.2022.920162
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