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Chemoenzymatic Synthesis of Asymmetrically Branched Human Milk Oligosaccharide Lacto-N-Hexaose

We herein reported the first chemoenzymatic synthesis of lacto-N-hexaose (LNH) by combining chemical carbohydrate synthesis with a selectively enzymatic glycosylation strategy. A tetrasaccharide core structure GlcNH(2)β1→3 (GlcNAcβ1→6) Galβ1→4Glc, a key precursor for subsequent enzymatic glycan exte...

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Detalles Bibliográficos
Autores principales:	Ooi, Kai-Eng, Zhang, Xiu-Wen, Kuo, Cheng-Yu, Liu, Ying-Jia, Yu, Ching-Ching
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194828/ https://www.ncbi.nlm.nih.gov/pubmed/35711960 http://dx.doi.org/10.3389/fchem.2022.905105

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