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Hybrid Antimicrobial Films Containing a Polyoxometalate-Ionic Liquid

[Image: see text] The increasing resistance of pathogenic microorganisms against common treatments requires innovative concepts to prevent infection and avoid long-term microbe viability on commonly used surfaces. Here, we report the preparation of a hybrid antimicrobial material based on the combin...

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Autores principales: Enderle, Ana G., Franco-Castillo, Isabel, Atrián-Blasco, Elena, Martín-Rapún, Rafael, Lizarraga, Leonardo, Culzoni, María J., Bollini, Mariela, de la Fuente, Jesús M., Silva, Filomena, Streb, Carsten, Mitchell, Scott G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194901/
https://www.ncbi.nlm.nih.gov/pubmed/35720671
http://dx.doi.org/10.1021/acsapm.2c00110
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author Enderle, Ana G.
Franco-Castillo, Isabel
Atrián-Blasco, Elena
Martín-Rapún, Rafael
Lizarraga, Leonardo
Culzoni, María J.
Bollini, Mariela
de la Fuente, Jesús M.
Silva, Filomena
Streb, Carsten
Mitchell, Scott G.
author_facet Enderle, Ana G.
Franco-Castillo, Isabel
Atrián-Blasco, Elena
Martín-Rapún, Rafael
Lizarraga, Leonardo
Culzoni, María J.
Bollini, Mariela
de la Fuente, Jesús M.
Silva, Filomena
Streb, Carsten
Mitchell, Scott G.
author_sort Enderle, Ana G.
collection PubMed
description [Image: see text] The increasing resistance of pathogenic microorganisms against common treatments requires innovative concepts to prevent infection and avoid long-term microbe viability on commonly used surfaces. Here, we report the preparation of a hybrid antimicrobial material based on the combination of microbiocidal polyoxometalate-ionic liquids (POM-ILs) and a biocompatible polymeric support, which enables the development of surface coatings that prevent microbial adhesion. The composite material is based on an antibacterial and antifungal room-temperature POM-IL composed of guanidinium cations (N,N,N′,N′-tetramethyl-N″, N″-dioctylguanidinum) combined with lacunary Keggin-type polyoxotungstate anions, [α-SiW(11)O(39)](8–). Integration of the antimicrobial POM-IL into the biocompatible, flexible, and stable polymer poly(methyl methacrylate) (PMMA) results in processable films, which are suitable as surface coatings or packaging materials to limit the proliferation and spread of pathogenic microorganisms (e.g., on public transport and hospital surfaces, or in ready-to-eat-food packaging).
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spelling pubmed-91949012022-06-15 Hybrid Antimicrobial Films Containing a Polyoxometalate-Ionic Liquid Enderle, Ana G. Franco-Castillo, Isabel Atrián-Blasco, Elena Martín-Rapún, Rafael Lizarraga, Leonardo Culzoni, María J. Bollini, Mariela de la Fuente, Jesús M. Silva, Filomena Streb, Carsten Mitchell, Scott G. ACS Appl Polym Mater [Image: see text] The increasing resistance of pathogenic microorganisms against common treatments requires innovative concepts to prevent infection and avoid long-term microbe viability on commonly used surfaces. Here, we report the preparation of a hybrid antimicrobial material based on the combination of microbiocidal polyoxometalate-ionic liquids (POM-ILs) and a biocompatible polymeric support, which enables the development of surface coatings that prevent microbial adhesion. The composite material is based on an antibacterial and antifungal room-temperature POM-IL composed of guanidinium cations (N,N,N′,N′-tetramethyl-N″, N″-dioctylguanidinum) combined with lacunary Keggin-type polyoxotungstate anions, [α-SiW(11)O(39)](8–). Integration of the antimicrobial POM-IL into the biocompatible, flexible, and stable polymer poly(methyl methacrylate) (PMMA) results in processable films, which are suitable as surface coatings or packaging materials to limit the proliferation and spread of pathogenic microorganisms (e.g., on public transport and hospital surfaces, or in ready-to-eat-food packaging). American Chemical Society 2022-04-12 2022-06-10 /pmc/articles/PMC9194901/ /pubmed/35720671 http://dx.doi.org/10.1021/acsapm.2c00110 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Enderle, Ana G.
Franco-Castillo, Isabel
Atrián-Blasco, Elena
Martín-Rapún, Rafael
Lizarraga, Leonardo
Culzoni, María J.
Bollini, Mariela
de la Fuente, Jesús M.
Silva, Filomena
Streb, Carsten
Mitchell, Scott G.
Hybrid Antimicrobial Films Containing a Polyoxometalate-Ionic Liquid
title Hybrid Antimicrobial Films Containing a Polyoxometalate-Ionic Liquid
title_full Hybrid Antimicrobial Films Containing a Polyoxometalate-Ionic Liquid
title_fullStr Hybrid Antimicrobial Films Containing a Polyoxometalate-Ionic Liquid
title_full_unstemmed Hybrid Antimicrobial Films Containing a Polyoxometalate-Ionic Liquid
title_short Hybrid Antimicrobial Films Containing a Polyoxometalate-Ionic Liquid
title_sort hybrid antimicrobial films containing a polyoxometalate-ionic liquid
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194901/
https://www.ncbi.nlm.nih.gov/pubmed/35720671
http://dx.doi.org/10.1021/acsapm.2c00110
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