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Stereocontrolled access to δ-lactone-fused-γ-lactams bearing angular benzylic quaternary stereocenters
C-fused γ-lactam-lactones are resident in several bioactive molecules, including anticancer agents such as omuralide. In this embodiment, we report mild conditions for the catalytic halolactonization of lactam-tethered 5-aryl-4(E)-pentenoic acids. The use of dichloromethane as the solvent and Ph(3)P...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194931/ https://www.ncbi.nlm.nih.gov/pubmed/35765420 http://dx.doi.org/10.1039/d2ra02167f |