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Total synthesis, structure revision and cytotoxic activity of Sch 53825 and its derivatives

The first total synthesis of Sch 53825 (14) was achieved in 12 steps from 5-hydroxy-1-tetralone in 16% overall yield through N-benzyl cinchoninium chloride-catalyzed asymmetric epoxidation and a Mitsunobu reaction as the key steps. On this basis, the synthesis of palmarumycin B(6) was improved using...

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Detalles Bibliográficos
Autores principales:	Xu, Leichuan, Ma, Haoyun, An, Xinkun, Li, Yihao, Zhang, Qian, Liu, Xinlei, Wang, Mingan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194939/ https://www.ncbi.nlm.nih.gov/pubmed/35765427 http://dx.doi.org/10.1039/d2ra02898k

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