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Total synthesis, structure revision and cytotoxic activity of Sch 53825 and its derivatives
The first total synthesis of Sch 53825 (14) was achieved in 12 steps from 5-hydroxy-1-tetralone in 16% overall yield through N-benzyl cinchoninium chloride-catalyzed asymmetric epoxidation and a Mitsunobu reaction as the key steps. On this basis, the synthesis of palmarumycin B(6) was improved using...
Autores principales: | Xu, Leichuan, Ma, Haoyun, An, Xinkun, Li, Yihao, Zhang, Qian, Liu, Xinlei, Wang, Mingan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194939/ https://www.ncbi.nlm.nih.gov/pubmed/35765427 http://dx.doi.org/10.1039/d2ra02898k |
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