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Green innovative fluorescence approach for the feasible and reliable assay of thiol-containing drugs; captopril as a model

In the present study, a novel spectrofluorimetric approach was designed for the analysis of captopril as a thiol-containing compound. The approach is based on the formation of a ternary fluorescent compound between the target thiol compound, ortho-phthaldehyde, and a suitable primary amine-containin...

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Autores principales: Derayea, Sayed M., Nagy, Dalia M., Badr El-Din, Khalid M., Attia, Tamer Z., Samir, Ebtihal, Mohamed, Abobakr A., Hamad, Ahmed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194952/
https://www.ncbi.nlm.nih.gov/pubmed/35765458
http://dx.doi.org/10.1039/d2ra02408j
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author Derayea, Sayed M.
Nagy, Dalia M.
Badr El-Din, Khalid M.
Attia, Tamer Z.
Samir, Ebtihal
Mohamed, Abobakr A.
Hamad, Ahmed A.
author_facet Derayea, Sayed M.
Nagy, Dalia M.
Badr El-Din, Khalid M.
Attia, Tamer Z.
Samir, Ebtihal
Mohamed, Abobakr A.
Hamad, Ahmed A.
author_sort Derayea, Sayed M.
collection PubMed
description In the present study, a novel spectrofluorimetric approach was designed for the analysis of captopril as a thiol-containing compound. The approach is based on the formation of a ternary fluorescent compound between the target thiol compound, ortho-phthaldehyde, and a suitable primary amine-containing compound. The produced 1-thio-alkyl-isoindole derivative exhibited very high emission activity in a faintly alkaline aqueous solution that could be monitored at 448 nm (excitation at 334 nm). 2-Amino-6-methyl-6-hydroxy-heptane was selected as the primary amine candidate that gave the high fluorescence intensity with the stability of the formed product. At the optimal experimental condition, the intensity of fluorescence of the formed product was linearly related to the concentration of captopril in 20–450 ng mL(−1) range. Commercial pharmaceutical tablets were analyzed, and the obtained results agreed with those of the published method regarding precision and accuracy. The mechanism of the reaction was discussed. In addition, the greenness of the approach was rated following eco-scale criteria.
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spelling pubmed-91949522022-06-27 Green innovative fluorescence approach for the feasible and reliable assay of thiol-containing drugs; captopril as a model Derayea, Sayed M. Nagy, Dalia M. Badr El-Din, Khalid M. Attia, Tamer Z. Samir, Ebtihal Mohamed, Abobakr A. Hamad, Ahmed A. RSC Adv Chemistry In the present study, a novel spectrofluorimetric approach was designed for the analysis of captopril as a thiol-containing compound. The approach is based on the formation of a ternary fluorescent compound between the target thiol compound, ortho-phthaldehyde, and a suitable primary amine-containing compound. The produced 1-thio-alkyl-isoindole derivative exhibited very high emission activity in a faintly alkaline aqueous solution that could be monitored at 448 nm (excitation at 334 nm). 2-Amino-6-methyl-6-hydroxy-heptane was selected as the primary amine candidate that gave the high fluorescence intensity with the stability of the formed product. At the optimal experimental condition, the intensity of fluorescence of the formed product was linearly related to the concentration of captopril in 20–450 ng mL(−1) range. Commercial pharmaceutical tablets were analyzed, and the obtained results agreed with those of the published method regarding precision and accuracy. The mechanism of the reaction was discussed. In addition, the greenness of the approach was rated following eco-scale criteria. The Royal Society of Chemistry 2022-06-14 /pmc/articles/PMC9194952/ /pubmed/35765458 http://dx.doi.org/10.1039/d2ra02408j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Derayea, Sayed M.
Nagy, Dalia M.
Badr El-Din, Khalid M.
Attia, Tamer Z.
Samir, Ebtihal
Mohamed, Abobakr A.
Hamad, Ahmed A.
Green innovative fluorescence approach for the feasible and reliable assay of thiol-containing drugs; captopril as a model
title Green innovative fluorescence approach for the feasible and reliable assay of thiol-containing drugs; captopril as a model
title_full Green innovative fluorescence approach for the feasible and reliable assay of thiol-containing drugs; captopril as a model
title_fullStr Green innovative fluorescence approach for the feasible and reliable assay of thiol-containing drugs; captopril as a model
title_full_unstemmed Green innovative fluorescence approach for the feasible and reliable assay of thiol-containing drugs; captopril as a model
title_short Green innovative fluorescence approach for the feasible and reliable assay of thiol-containing drugs; captopril as a model
title_sort green innovative fluorescence approach for the feasible and reliable assay of thiol-containing drugs; captopril as a model
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194952/
https://www.ncbi.nlm.nih.gov/pubmed/35765458
http://dx.doi.org/10.1039/d2ra02408j
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