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Beam commissioning of the first clinical biology‐guided radiotherapy system

This study reports the beam commissioning results for the first clinical RefleXion Linac. Methods: The X1 produces a 6 MV photon beam and the maximum clinical field size is 40 × 2 cm(2) at source‐to‐axis distance of 85 cm. Treatment fields are collimated by a binary multileaf collimator (MLC) system...

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Autores principales: Han, Bin, Capaldi, Dante, Kovalchuk, Nataliya, Simiele, Eric, White, John, Zaks, Daniel, Xing, Lei, Surucu, Murat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194984/
https://www.ncbi.nlm.nih.gov/pubmed/35482018
http://dx.doi.org/10.1002/acm2.13607
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author Han, Bin
Capaldi, Dante
Kovalchuk, Nataliya
Simiele, Eric
White, John
Zaks, Daniel
Xing, Lei
Surucu, Murat
author_facet Han, Bin
Capaldi, Dante
Kovalchuk, Nataliya
Simiele, Eric
White, John
Zaks, Daniel
Xing, Lei
Surucu, Murat
author_sort Han, Bin
collection PubMed
description This study reports the beam commissioning results for the first clinical RefleXion Linac. Methods: The X1 produces a 6 MV photon beam and the maximum clinical field size is 40 × 2 cm(2) at source‐to‐axis distance of 85 cm. Treatment fields are collimated by a binary multileaf collimator (MLC) system with 64 leaves with width of 0.625 cm and y‐jaw pairs to provide either a 1 or 2 cm opening. The mechanical alignment of the radiation source, the y‐jaw, and MLC were checked with film and ion chambers. The beam parameters were characterized using a diode detector in a compact water tank. In‐air lateral profiles and in‐water percentage depth dose (PDD) were measured for beam modeling of the treatment planning system (TPS). The lateral profiles, PDDs, and output factors were acquired for field sizes from 1.25 × 1 to 40 × 2 cm(2) field to verify the beam modeling. The rotational output variation and synchronicity were tested to check the gantry angle, couch motion, and gantry rotation. Results: The source misalignments were 0.049 mm in y‐direction, 0.66% out‐of‐focus in x‐direction. The divergence of the beam axis was 0.36 mm with a y‐jaw twist of 0.03°. Clinical off‐axis treatment fields shared a common center in y‐direction were within 0.03 mm. The MLC misalignment and twist were 0.57 mm and 0.15°. For all measured fields ranging from the size from 1.25 × 1 to 40 × 2 cm(2), the mean difference between measured and TPS modeled PDD at 10 cm depth was −0.3%. The mean transverse profile difference in the field core was −0.3% ± 1.1%. The full‐width half maximum (FWHM) modeling was within 0.5 mm. The measured output factors agreed with TPS within 0.8%. Conclusions: This study summarizes our specific experience commissioning the first novel RefleXion linac, which may assist future users of this technology when implementing it into their own clinics.
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spelling pubmed-91949842022-06-21 Beam commissioning of the first clinical biology‐guided radiotherapy system Han, Bin Capaldi, Dante Kovalchuk, Nataliya Simiele, Eric White, John Zaks, Daniel Xing, Lei Surucu, Murat J Appl Clin Med Phys Radiation Oncology Physics This study reports the beam commissioning results for the first clinical RefleXion Linac. Methods: The X1 produces a 6 MV photon beam and the maximum clinical field size is 40 × 2 cm(2) at source‐to‐axis distance of 85 cm. Treatment fields are collimated by a binary multileaf collimator (MLC) system with 64 leaves with width of 0.625 cm and y‐jaw pairs to provide either a 1 or 2 cm opening. The mechanical alignment of the radiation source, the y‐jaw, and MLC were checked with film and ion chambers. The beam parameters were characterized using a diode detector in a compact water tank. In‐air lateral profiles and in‐water percentage depth dose (PDD) were measured for beam modeling of the treatment planning system (TPS). The lateral profiles, PDDs, and output factors were acquired for field sizes from 1.25 × 1 to 40 × 2 cm(2) field to verify the beam modeling. The rotational output variation and synchronicity were tested to check the gantry angle, couch motion, and gantry rotation. Results: The source misalignments were 0.049 mm in y‐direction, 0.66% out‐of‐focus in x‐direction. The divergence of the beam axis was 0.36 mm with a y‐jaw twist of 0.03°. Clinical off‐axis treatment fields shared a common center in y‐direction were within 0.03 mm. The MLC misalignment and twist were 0.57 mm and 0.15°. For all measured fields ranging from the size from 1.25 × 1 to 40 × 2 cm(2), the mean difference between measured and TPS modeled PDD at 10 cm depth was −0.3%. The mean transverse profile difference in the field core was −0.3% ± 1.1%. The full‐width half maximum (FWHM) modeling was within 0.5 mm. The measured output factors agreed with TPS within 0.8%. Conclusions: This study summarizes our specific experience commissioning the first novel RefleXion linac, which may assist future users of this technology when implementing it into their own clinics. John Wiley and Sons Inc. 2022-04-28 /pmc/articles/PMC9194984/ /pubmed/35482018 http://dx.doi.org/10.1002/acm2.13607 Text en © 2022 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, LLC on behalf of The American Association of Physicists in Medicine. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Han, Bin
Capaldi, Dante
Kovalchuk, Nataliya
Simiele, Eric
White, John
Zaks, Daniel
Xing, Lei
Surucu, Murat
Beam commissioning of the first clinical biology‐guided radiotherapy system
title Beam commissioning of the first clinical biology‐guided radiotherapy system
title_full Beam commissioning of the first clinical biology‐guided radiotherapy system
title_fullStr Beam commissioning of the first clinical biology‐guided radiotherapy system
title_full_unstemmed Beam commissioning of the first clinical biology‐guided radiotherapy system
title_short Beam commissioning of the first clinical biology‐guided radiotherapy system
title_sort beam commissioning of the first clinical biology‐guided radiotherapy system
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194984/
https://www.ncbi.nlm.nih.gov/pubmed/35482018
http://dx.doi.org/10.1002/acm2.13607
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