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Cell migration orchestrates migrasome formation by shaping retraction fibers
Migrasomes are recently discovered vesicle-like structures on retraction fibers of migrating cells that have been linked with transfer of cellular contents, shedding of unwanted materials, and information integration. However, whether and how the cell migration paradigm regulates migrasome formation...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9195050/ https://www.ncbi.nlm.nih.gov/pubmed/35179563 http://dx.doi.org/10.1083/jcb.202109168 |
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author | Fan, Changyuan Shi, Xuemeng Zhao, Kaikai Wang, Linbo Shi, Kun Liu, Yan-Jun Li, Hui Ji, Baohua Jiu, Yaming |
author_facet | Fan, Changyuan Shi, Xuemeng Zhao, Kaikai Wang, Linbo Shi, Kun Liu, Yan-Jun Li, Hui Ji, Baohua Jiu, Yaming |
author_sort | Fan, Changyuan |
collection | PubMed |
description | Migrasomes are recently discovered vesicle-like structures on retraction fibers of migrating cells that have been linked with transfer of cellular contents, shedding of unwanted materials, and information integration. However, whether and how the cell migration paradigm regulates migrasome formation is not clear. Here, we report that there are significantly fewer migrasomes in turning cells compared with straight persistently migrating cells. The major insight underlying this observation is that as the cells elongate, their rear ends become narrower, subsequently resulting in fewer retraction fibers during impersistent migration. In addition to migration persistence, we reveal that migration speed positively corelates with migrasome formation, owing to the derived length of retraction fibers. Substantiating our hypothesis, genetically removing vimentin compromises cell migration speed and persistence and leads to fewer migrasomes. Together, our data explicate the critical roles of two cell migration patterns, persistence and speed, in the control of migrasome formation by regulating retraction fibers. |
format | Online Article Text |
id | pubmed-9195050 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-91950502022-10-04 Cell migration orchestrates migrasome formation by shaping retraction fibers Fan, Changyuan Shi, Xuemeng Zhao, Kaikai Wang, Linbo Shi, Kun Liu, Yan-Jun Li, Hui Ji, Baohua Jiu, Yaming J Cell Biol Report Migrasomes are recently discovered vesicle-like structures on retraction fibers of migrating cells that have been linked with transfer of cellular contents, shedding of unwanted materials, and information integration. However, whether and how the cell migration paradigm regulates migrasome formation is not clear. Here, we report that there are significantly fewer migrasomes in turning cells compared with straight persistently migrating cells. The major insight underlying this observation is that as the cells elongate, their rear ends become narrower, subsequently resulting in fewer retraction fibers during impersistent migration. In addition to migration persistence, we reveal that migration speed positively corelates with migrasome formation, owing to the derived length of retraction fibers. Substantiating our hypothesis, genetically removing vimentin compromises cell migration speed and persistence and leads to fewer migrasomes. Together, our data explicate the critical roles of two cell migration patterns, persistence and speed, in the control of migrasome formation by regulating retraction fibers. Rockefeller University Press 2022-02-18 /pmc/articles/PMC9195050/ /pubmed/35179563 http://dx.doi.org/10.1083/jcb.202109168 Text en This is a work of the U.S. Government and is not subject to copyright protection in the United States. Foreign copyrights may apply. https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Report Fan, Changyuan Shi, Xuemeng Zhao, Kaikai Wang, Linbo Shi, Kun Liu, Yan-Jun Li, Hui Ji, Baohua Jiu, Yaming Cell migration orchestrates migrasome formation by shaping retraction fibers |
title | Cell migration orchestrates migrasome formation by shaping retraction fibers |
title_full | Cell migration orchestrates migrasome formation by shaping retraction fibers |
title_fullStr | Cell migration orchestrates migrasome formation by shaping retraction fibers |
title_full_unstemmed | Cell migration orchestrates migrasome formation by shaping retraction fibers |
title_short | Cell migration orchestrates migrasome formation by shaping retraction fibers |
title_sort | cell migration orchestrates migrasome formation by shaping retraction fibers |
topic | Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9195050/ https://www.ncbi.nlm.nih.gov/pubmed/35179563 http://dx.doi.org/10.1083/jcb.202109168 |
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