Metal Ion Binding in Wild-Type and Mutated Frataxin: A Stability Study

This work studies the stability of wild-type frataxin and some of its variants found in cancer tissues upon Co(2+) binding. Although the physiologically involved metal ion in the frataxin enzymatic activity is Fe(2+), as it is customarily done, Co(2+) is most often used in experiments because Fe(2+)...

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Detalles Bibliográficos
Autores principales: Morante, S., Botticelli, S., Chiaraluce, R., Consalvi, V., La Penna, G., Novak, L., Pasquo, A., Petrosino, M., Proux, O., Rossi, G., Salina, G., Stellato, F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9195147/
https://www.ncbi.nlm.nih.gov/pubmed/35712353
http://dx.doi.org/10.3389/fmolb.2022.878017

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