Cargando…

Immune characteristics of children with autoimmune encephalitis and the correlation with a short-term prognosis

BACKGROUND: Autoimmune encephalitis (AE) is a type of encephalopathy mediated by an antigenic immune response in the central nervous system. Most research related to autoimmune encephalitis (AE) is focused on early diagnosis, treatment and prognosis analysis; there has been little research conducted...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Jin-Yue, Fan, Wen-Xuan, Meng, Jing, Cai, Chun-Quan, Li, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9195209/
https://www.ncbi.nlm.nih.gov/pubmed/35698204
http://dx.doi.org/10.1186/s13052-022-01247-0
_version_ 1784726919065894912
author Huang, Jin-Yue
Fan, Wen-Xuan
Meng, Jing
Cai, Chun-Quan
Li, Dong
author_facet Huang, Jin-Yue
Fan, Wen-Xuan
Meng, Jing
Cai, Chun-Quan
Li, Dong
author_sort Huang, Jin-Yue
collection PubMed
description BACKGROUND: Autoimmune encephalitis (AE) is a type of encephalopathy mediated by an antigenic immune response in the central nervous system. Most research related to autoimmune encephalitis (AE) is focused on early diagnosis, treatment and prognosis analysis; there has been little research conducted on the characteristics of immune function, and the relationship between immune function and prognoses of patients with autoimmune encephalitis needs to be studied further. METHODS: A total of 33 children with autoimmune encephalitis were identified through the clinic database and inpatient consults at Tianjin Children’s Hospital from January 2013 to January 2021. Based on the one-year follow-up and the modified Rankin Scale (mRS) prognosis score, they were divided into a good prognosis group and a poor prognosis group. The immune function characteristics of the two groups of children with autoimmune encephalitis (AE) were compared using Spearman correlation to analyse the mRS score and immune function indicators (IgA, IgG, IgM, CD4, CD8, CD4/CD8), and binary logistic regression was used to analyse the independent risk factors of the prognoses in patients with autoimmune encephalitis (AE). RESULTS: The differences in abnormal mental disorders and limb dyskinesia, cognitive impairment, onset types, modified Rankin Scale (mRS) scores at admission, and immune function status during remission between the two groups were statistically significant (p < 0.05). CONCLUSION: There is a close correlation between modified Rankin Scale (mRS) scores and the immune function index CD4/CD8 in children with autoimmune encephalitis (AE) when they are admitted to the hospital. A young age, disturbance of consciousness, limb dyskinesia, abnormal immune function in remission and anti-NMDAR encephalitis are risk factors for poor prognoses in children with autoimmune encephalitis (AE). Clinical treatment requires more attention.
format Online
Article
Text
id pubmed-9195209
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-91952092022-06-15 Immune characteristics of children with autoimmune encephalitis and the correlation with a short-term prognosis Huang, Jin-Yue Fan, Wen-Xuan Meng, Jing Cai, Chun-Quan Li, Dong Ital J Pediatr Research BACKGROUND: Autoimmune encephalitis (AE) is a type of encephalopathy mediated by an antigenic immune response in the central nervous system. Most research related to autoimmune encephalitis (AE) is focused on early diagnosis, treatment and prognosis analysis; there has been little research conducted on the characteristics of immune function, and the relationship between immune function and prognoses of patients with autoimmune encephalitis needs to be studied further. METHODS: A total of 33 children with autoimmune encephalitis were identified through the clinic database and inpatient consults at Tianjin Children’s Hospital from January 2013 to January 2021. Based on the one-year follow-up and the modified Rankin Scale (mRS) prognosis score, they were divided into a good prognosis group and a poor prognosis group. The immune function characteristics of the two groups of children with autoimmune encephalitis (AE) were compared using Spearman correlation to analyse the mRS score and immune function indicators (IgA, IgG, IgM, CD4, CD8, CD4/CD8), and binary logistic regression was used to analyse the independent risk factors of the prognoses in patients with autoimmune encephalitis (AE). RESULTS: The differences in abnormal mental disorders and limb dyskinesia, cognitive impairment, onset types, modified Rankin Scale (mRS) scores at admission, and immune function status during remission between the two groups were statistically significant (p < 0.05). CONCLUSION: There is a close correlation between modified Rankin Scale (mRS) scores and the immune function index CD4/CD8 in children with autoimmune encephalitis (AE) when they are admitted to the hospital. A young age, disturbance of consciousness, limb dyskinesia, abnormal immune function in remission and anti-NMDAR encephalitis are risk factors for poor prognoses in children with autoimmune encephalitis (AE). Clinical treatment requires more attention. BioMed Central 2022-06-13 /pmc/articles/PMC9195209/ /pubmed/35698204 http://dx.doi.org/10.1186/s13052-022-01247-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Huang, Jin-Yue
Fan, Wen-Xuan
Meng, Jing
Cai, Chun-Quan
Li, Dong
Immune characteristics of children with autoimmune encephalitis and the correlation with a short-term prognosis
title Immune characteristics of children with autoimmune encephalitis and the correlation with a short-term prognosis
title_full Immune characteristics of children with autoimmune encephalitis and the correlation with a short-term prognosis
title_fullStr Immune characteristics of children with autoimmune encephalitis and the correlation with a short-term prognosis
title_full_unstemmed Immune characteristics of children with autoimmune encephalitis and the correlation with a short-term prognosis
title_short Immune characteristics of children with autoimmune encephalitis and the correlation with a short-term prognosis
title_sort immune characteristics of children with autoimmune encephalitis and the correlation with a short-term prognosis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9195209/
https://www.ncbi.nlm.nih.gov/pubmed/35698204
http://dx.doi.org/10.1186/s13052-022-01247-0
work_keys_str_mv AT huangjinyue immunecharacteristicsofchildrenwithautoimmuneencephalitisandthecorrelationwithashorttermprognosis
AT fanwenxuan immunecharacteristicsofchildrenwithautoimmuneencephalitisandthecorrelationwithashorttermprognosis
AT mengjing immunecharacteristicsofchildrenwithautoimmuneencephalitisandthecorrelationwithashorttermprognosis
AT caichunquan immunecharacteristicsofchildrenwithautoimmuneencephalitisandthecorrelationwithashorttermprognosis
AT lidong immunecharacteristicsofchildrenwithautoimmuneencephalitisandthecorrelationwithashorttermprognosis