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High Expression of RECQL Protein in ER-Positive Breast Tumours Is Associated With a Better Survival

BACKGROUND: RECQL (also known as RECQ1 and RECQL1) is a gene of recent interest in breast cancer and an association between high levels of RECQL protein in breast cancer tumour cells and good survival of patients has been reported. METHODS: To validate this association, we measured the RECQL protein...

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Autores principales: Mahmoodi, Ardalan, Shoqafi, Ahmed, Sun, Ping, Giannakeas, Vasily, Cybulski, Cezary, Nofech-Mozes, Sharon, Masson, Jean-Yves, Sharma, Sudha, Samani, Amir Abbas, Madhusudan, Srinivasan, Narod, Steven A., Akbari, Mohammad R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9195420/
https://www.ncbi.nlm.nih.gov/pubmed/35712517
http://dx.doi.org/10.3389/fonc.2022.877617
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author Mahmoodi, Ardalan
Shoqafi, Ahmed
Sun, Ping
Giannakeas, Vasily
Cybulski, Cezary
Nofech-Mozes, Sharon
Masson, Jean-Yves
Sharma, Sudha
Samani, Amir Abbas
Madhusudan, Srinivasan
Narod, Steven A.
Akbari, Mohammad R.
author_facet Mahmoodi, Ardalan
Shoqafi, Ahmed
Sun, Ping
Giannakeas, Vasily
Cybulski, Cezary
Nofech-Mozes, Sharon
Masson, Jean-Yves
Sharma, Sudha
Samani, Amir Abbas
Madhusudan, Srinivasan
Narod, Steven A.
Akbari, Mohammad R.
author_sort Mahmoodi, Ardalan
collection PubMed
description BACKGROUND: RECQL (also known as RECQ1 and RECQL1) is a gene of recent interest in breast cancer and an association between high levels of RECQL protein in breast cancer tumour cells and good survival of patients has been reported. METHODS: To validate this association, we measured the RECQL protein levels in tumours of 933 breast cancer patients using immunohistochemistry analysis and followed the patients for death from breast cancer. RESULTS: Women with a level of RECQL protein above the 75th percentile had better 15-year disease-specific survival among ER-positive patients (62.5% vs. 48.7%, HR= 0.72, 95%CI= 0.52-0.98, p-value = 0.04), but not among ER- patients (48.9% vs. 48.0%, HR= 1.07, 95%CI= 0.67-1.69, p-value= 0.79). Among the ER-negative patients, high RECQL protein levels were associated with better survival among women who received tamoxifen treatment (67.0% vs. 51.5%, HR= 0.64, 95%CI= 0.41-0.99, p-value= 0.04). CONCLUSION: RECQL might be a new predictive marker for tamoxifen treatment among ER-positive patients.
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spelling pubmed-91954202022-06-15 High Expression of RECQL Protein in ER-Positive Breast Tumours Is Associated With a Better Survival Mahmoodi, Ardalan Shoqafi, Ahmed Sun, Ping Giannakeas, Vasily Cybulski, Cezary Nofech-Mozes, Sharon Masson, Jean-Yves Sharma, Sudha Samani, Amir Abbas Madhusudan, Srinivasan Narod, Steven A. Akbari, Mohammad R. Front Oncol Oncology BACKGROUND: RECQL (also known as RECQ1 and RECQL1) is a gene of recent interest in breast cancer and an association between high levels of RECQL protein in breast cancer tumour cells and good survival of patients has been reported. METHODS: To validate this association, we measured the RECQL protein levels in tumours of 933 breast cancer patients using immunohistochemistry analysis and followed the patients for death from breast cancer. RESULTS: Women with a level of RECQL protein above the 75th percentile had better 15-year disease-specific survival among ER-positive patients (62.5% vs. 48.7%, HR= 0.72, 95%CI= 0.52-0.98, p-value = 0.04), but not among ER- patients (48.9% vs. 48.0%, HR= 1.07, 95%CI= 0.67-1.69, p-value= 0.79). Among the ER-negative patients, high RECQL protein levels were associated with better survival among women who received tamoxifen treatment (67.0% vs. 51.5%, HR= 0.64, 95%CI= 0.41-0.99, p-value= 0.04). CONCLUSION: RECQL might be a new predictive marker for tamoxifen treatment among ER-positive patients. Frontiers Media S.A. 2022-05-31 /pmc/articles/PMC9195420/ /pubmed/35712517 http://dx.doi.org/10.3389/fonc.2022.877617 Text en Copyright © 2022 Mahmoodi, Shoqafi, Sun, Giannakeas, Cybulski, Nofech-Mozes, Masson, Sharma, Samani, Madhusudan, Narod and Akbari https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Mahmoodi, Ardalan
Shoqafi, Ahmed
Sun, Ping
Giannakeas, Vasily
Cybulski, Cezary
Nofech-Mozes, Sharon
Masson, Jean-Yves
Sharma, Sudha
Samani, Amir Abbas
Madhusudan, Srinivasan
Narod, Steven A.
Akbari, Mohammad R.
High Expression of RECQL Protein in ER-Positive Breast Tumours Is Associated With a Better Survival
title High Expression of RECQL Protein in ER-Positive Breast Tumours Is Associated With a Better Survival
title_full High Expression of RECQL Protein in ER-Positive Breast Tumours Is Associated With a Better Survival
title_fullStr High Expression of RECQL Protein in ER-Positive Breast Tumours Is Associated With a Better Survival
title_full_unstemmed High Expression of RECQL Protein in ER-Positive Breast Tumours Is Associated With a Better Survival
title_short High Expression of RECQL Protein in ER-Positive Breast Tumours Is Associated With a Better Survival
title_sort high expression of recql protein in er-positive breast tumours is associated with a better survival
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9195420/
https://www.ncbi.nlm.nih.gov/pubmed/35712517
http://dx.doi.org/10.3389/fonc.2022.877617
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