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Novel computer-aided reconstruction of soft tissue defects following resection of oral and oropharyngeal squamous cell carcinoma

BACKGROUND: Reconstruction of soft tissue defects following surgical tumor resection is important for quality of life in cancer patients with oral and oropharyngeal squamous cell carcinoma (SCC). This study presents a novel computer-aided reconstruction of soft tissue (CARST) technology employed wit...

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Autores principales: Xu, Jiajie, Lai, Fangyuan, Liu, Yunfeng, Tan, Zhuo, Zheng, Chuanming, Wang, Jiafeng, Guo, Haiwei, Jiang, Liehao, Ge, Xinyang, Lan, Xiabin, Chen, Chao, Ge, Minghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9195432/
https://www.ncbi.nlm.nih.gov/pubmed/35698194
http://dx.doi.org/10.1186/s12957-022-02654-7
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author Xu, Jiajie
Lai, Fangyuan
Liu, Yunfeng
Tan, Zhuo
Zheng, Chuanming
Wang, Jiafeng
Guo, Haiwei
Jiang, Liehao
Ge, Xinyang
Lan, Xiabin
Chen, Chao
Ge, Minghua
author_facet Xu, Jiajie
Lai, Fangyuan
Liu, Yunfeng
Tan, Zhuo
Zheng, Chuanming
Wang, Jiafeng
Guo, Haiwei
Jiang, Liehao
Ge, Xinyang
Lan, Xiabin
Chen, Chao
Ge, Minghua
author_sort Xu, Jiajie
collection PubMed
description BACKGROUND: Reconstruction of soft tissue defects following surgical tumor resection is important for quality of life in cancer patients with oral and oropharyngeal squamous cell carcinoma (SCC). This study presents a novel computer-aided reconstruction of soft tissue (CARST) technology employed with these patients. METHODS: We first described the CARST technology in detail in a report of a 34-year-old male patient with locally invasive right-sided tongue SCC following a nearly total glossectomy and reported the postoperative outcomes. This digital technology was applied to construct a 3D model from CT images, which was used to delineate surgical resection boundaries and design a personalized reconstruction of the soft tissue defect. A nonuniform rational B-spline (NURBS) was generated and applied to transform the 3D model into a 2D flap-cutting guide printed out using a 3D printer. We then reported a case-series study on oral and oropharyngeal SCC patients who were randomly assigned to receive the CARST (n = 15) or a traditional soft tissue reconstruction (n = 15). Clinicopathological features and short- and long-term postoperative outcomes between the two groups were compared. RESULTS: The patient with the tongue SCC had a successful CARST following surgical tumor resection without any complications. His speech and swallowing functions recovered well after surgery and he experienced no significant changes to his appearance following recovery. There was no recurrence within a 3-year follow-up period. Results of the case-series study showed that the CARST group had significantly shorter operative and post-operation hospital-stay time, a higher flap utilization rate, and a trend of less and milder postoperative complications, and they experienced no significant difference in intraoperative blood loss and long-term outcomes compared to the traditional group. CONCLUSION: CARST is a safer and more efficient personalized technology of soft tissue reconstruction following surgical tumor resection in patients with oral and oropharyngeal SCC. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12957-022-02654-7.
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spelling pubmed-91954322022-06-15 Novel computer-aided reconstruction of soft tissue defects following resection of oral and oropharyngeal squamous cell carcinoma Xu, Jiajie Lai, Fangyuan Liu, Yunfeng Tan, Zhuo Zheng, Chuanming Wang, Jiafeng Guo, Haiwei Jiang, Liehao Ge, Xinyang Lan, Xiabin Chen, Chao Ge, Minghua World J Surg Oncol Research BACKGROUND: Reconstruction of soft tissue defects following surgical tumor resection is important for quality of life in cancer patients with oral and oropharyngeal squamous cell carcinoma (SCC). This study presents a novel computer-aided reconstruction of soft tissue (CARST) technology employed with these patients. METHODS: We first described the CARST technology in detail in a report of a 34-year-old male patient with locally invasive right-sided tongue SCC following a nearly total glossectomy and reported the postoperative outcomes. This digital technology was applied to construct a 3D model from CT images, which was used to delineate surgical resection boundaries and design a personalized reconstruction of the soft tissue defect. A nonuniform rational B-spline (NURBS) was generated and applied to transform the 3D model into a 2D flap-cutting guide printed out using a 3D printer. We then reported a case-series study on oral and oropharyngeal SCC patients who were randomly assigned to receive the CARST (n = 15) or a traditional soft tissue reconstruction (n = 15). Clinicopathological features and short- and long-term postoperative outcomes between the two groups were compared. RESULTS: The patient with the tongue SCC had a successful CARST following surgical tumor resection without any complications. His speech and swallowing functions recovered well after surgery and he experienced no significant changes to his appearance following recovery. There was no recurrence within a 3-year follow-up period. Results of the case-series study showed that the CARST group had significantly shorter operative and post-operation hospital-stay time, a higher flap utilization rate, and a trend of less and milder postoperative complications, and they experienced no significant difference in intraoperative blood loss and long-term outcomes compared to the traditional group. CONCLUSION: CARST is a safer and more efficient personalized technology of soft tissue reconstruction following surgical tumor resection in patients with oral and oropharyngeal SCC. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12957-022-02654-7. BioMed Central 2022-06-13 /pmc/articles/PMC9195432/ /pubmed/35698194 http://dx.doi.org/10.1186/s12957-022-02654-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Xu, Jiajie
Lai, Fangyuan
Liu, Yunfeng
Tan, Zhuo
Zheng, Chuanming
Wang, Jiafeng
Guo, Haiwei
Jiang, Liehao
Ge, Xinyang
Lan, Xiabin
Chen, Chao
Ge, Minghua
Novel computer-aided reconstruction of soft tissue defects following resection of oral and oropharyngeal squamous cell carcinoma
title Novel computer-aided reconstruction of soft tissue defects following resection of oral and oropharyngeal squamous cell carcinoma
title_full Novel computer-aided reconstruction of soft tissue defects following resection of oral and oropharyngeal squamous cell carcinoma
title_fullStr Novel computer-aided reconstruction of soft tissue defects following resection of oral and oropharyngeal squamous cell carcinoma
title_full_unstemmed Novel computer-aided reconstruction of soft tissue defects following resection of oral and oropharyngeal squamous cell carcinoma
title_short Novel computer-aided reconstruction of soft tissue defects following resection of oral and oropharyngeal squamous cell carcinoma
title_sort novel computer-aided reconstruction of soft tissue defects following resection of oral and oropharyngeal squamous cell carcinoma
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9195432/
https://www.ncbi.nlm.nih.gov/pubmed/35698194
http://dx.doi.org/10.1186/s12957-022-02654-7
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