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Potential Benefits of TNF Targeting Therapy in Blau Syndrome, a NOD2-Associated Systemic Autoinflammatory Granulomatosis

Blau syndrome is a systemic autoinflammatory granulomatous disease caused by mutations in the nucleotide-binding oligomerization domain 2 (NOD2) gene. NOD2 is an intracellular pathogen recognition receptor. Upon binding to muramyl dipeptide (MDP), NOD2 activates the NF-κB pathway, leading to the upr...

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Detalles Bibliográficos
Autores principales:	Matsuda, Tomoko, Kambe, Naotomo, Takimoto-Ito, Riko, Ueki, Yoko, Nakamizo, Satoshi, Saito, Megumu K., Takei, Syuji, Kanazawa, Nobuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9195515/ https://www.ncbi.nlm.nih.gov/pubmed/35711422 http://dx.doi.org/10.3389/fimmu.2022.895765

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