Comparison of ondansetron and tropisetron in preventing postoperative nausea and vomiting: A meta-analysis of randomized controlled trials

OBJECTIVES: To compare the efficacy of prophylactic ondansetron and tropisetron for postoperative nausea and vomiting (PONV). METHODS: A literature search was performed to identify studies that compare the efficiency of ondansetron with that of tropisetron in preventing PONV. Only randomized control...

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Detalles Bibliográficos
Autores principales: Wang, Rui, Song, Xuesong, Chen, Yan, Wang, Na, Wang, Jinguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Saudi Medical Journal 2021
Materias:
Systematic Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9195535/
https://www.ncbi.nlm.nih.gov/pubmed/34187913
http://dx.doi.org/10.15537/smj.2021.42.7.20210135
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author Wang, Rui
Song, Xuesong
Chen, Yan
Wang, Na
Wang, Jinguo
author_facet Wang, Rui
Song, Xuesong
Chen, Yan
Wang, Na
Wang, Jinguo
author_sort Wang, Rui
collection PubMed
description OBJECTIVES: To compare the efficacy of prophylactic ondansetron and tropisetron for postoperative nausea and vomiting (PONV). METHODS: A literature search was performed to identify studies that compare the efficiency of ondansetron with that of tropisetron in preventing PONV. Only randomized controlled trials updated to January, 2021 were included. RESULTS: The final pooled analysis included 14 studies totaling 1705 patients and indicated that ondansetron was 39% less effective than tropisetron in preventing postoperative vomiting with a higher incidence of dizziness. However, no significant difference was detected between ondansetron and tropisetron in PONV, postoperative nausea, antiemetic treatment, and headache. CONCLUSIONS: Tropisetron is superior to ondansetron in preventing postoperative vomiting. PROSPERO No: CRD42021237368
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spelling pubmed-91955352022-06-21 Comparison of ondansetron and tropisetron in preventing postoperative nausea and vomiting: A meta-analysis of randomized controlled trials Wang, Rui Song, Xuesong Chen, Yan Wang, Na Wang, Jinguo Saudi Med J Systematic Review OBJECTIVES: To compare the efficacy of prophylactic ondansetron and tropisetron for postoperative nausea and vomiting (PONV). METHODS: A literature search was performed to identify studies that compare the efficiency of ondansetron with that of tropisetron in preventing PONV. Only randomized controlled trials updated to January, 2021 were included. RESULTS: The final pooled analysis included 14 studies totaling 1705 patients and indicated that ondansetron was 39% less effective than tropisetron in preventing postoperative vomiting with a higher incidence of dizziness. However, no significant difference was detected between ondansetron and tropisetron in PONV, postoperative nausea, antiemetic treatment, and headache. CONCLUSIONS: Tropisetron is superior to ondansetron in preventing postoperative vomiting. PROSPERO No: CRD42021237368 Saudi Medical Journal 2021-07 /pmc/articles/PMC9195535/ /pubmed/34187913 http://dx.doi.org/10.15537/smj.2021.42.7.20210135 Text en Copyright: © Saudi Medical Journal https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work.
spellingShingle Systematic Review
Wang, Rui
Song, Xuesong
Chen, Yan
Wang, Na
Wang, Jinguo
Comparison of ondansetron and tropisetron in preventing postoperative nausea and vomiting: A meta-analysis of randomized controlled trials
title Comparison of ondansetron and tropisetron in preventing postoperative nausea and vomiting: A meta-analysis of randomized controlled trials
title_full Comparison of ondansetron and tropisetron in preventing postoperative nausea and vomiting: A meta-analysis of randomized controlled trials
title_fullStr Comparison of ondansetron and tropisetron in preventing postoperative nausea and vomiting: A meta-analysis of randomized controlled trials
title_full_unstemmed Comparison of ondansetron and tropisetron in preventing postoperative nausea and vomiting: A meta-analysis of randomized controlled trials
title_short Comparison of ondansetron and tropisetron in preventing postoperative nausea and vomiting: A meta-analysis of randomized controlled trials
title_sort comparison of ondansetron and tropisetron in preventing postoperative nausea and vomiting: a meta-analysis of randomized controlled trials
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9195535/
https://www.ncbi.nlm.nih.gov/pubmed/34187913
http://dx.doi.org/10.15537/smj.2021.42.7.20210135
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