Novel STAT3 Inhibitors Targeting STAT3 Dimerization by Binding to the STAT3 SH2 Domain

Our drug discovery model has identified two novel STAT3 SH2 domain inhibitors 323–1 and 323–2 (delavatine A stereoisomers) in a series of experiments. In silico computational modeling, drug affinity responsive target stability (DARTS), and fluorescence polarization (FP) assays altogether determined...

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Detalles Bibliográficos
Autores principales: Hua, Yaping, Yuan, Xing, Shen, Yun-heng, Wang, Jinxin, Azeem, Waqas, Yang, Shuo, Gade, Alexandra, Lellahi, Seyed Mohammad, Øyan, Anne Margrete, Ke, Xisong, Zhang, Wei-dong, Kalland, Karl-Henning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9196127/
https://www.ncbi.nlm.nih.gov/pubmed/35712699
http://dx.doi.org/10.3389/fphar.2022.836724

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