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Potential Molecular Mechanisms of Recurrent and Progressive Meningiomas: A Review of the Latest Literature

Meningiomas, the most frequent primary intracranial tumors of the central nervous system in adults, originate from the meninges and meningeal spaces. Surgical resection and adjuvant radiation are considered the preferred treatment options. Although most meningiomas are benign and slow-growing, some...

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Autores principales: Peng, Wenjie, Wu, Pei, Yuan, Minghao, Yuan, Bo, Zhu, Lian, Zhou, Jiesong, Li, Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9196588/
https://www.ncbi.nlm.nih.gov/pubmed/35712491
http://dx.doi.org/10.3389/fonc.2022.850463
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author Peng, Wenjie
Wu, Pei
Yuan, Minghao
Yuan, Bo
Zhu, Lian
Zhou, Jiesong
Li, Qian
author_facet Peng, Wenjie
Wu, Pei
Yuan, Minghao
Yuan, Bo
Zhu, Lian
Zhou, Jiesong
Li, Qian
author_sort Peng, Wenjie
collection PubMed
description Meningiomas, the most frequent primary intracranial tumors of the central nervous system in adults, originate from the meninges and meningeal spaces. Surgical resection and adjuvant radiation are considered the preferred treatment options. Although most meningiomas are benign and slow-growing, some patients suffer from tumor recurrence and disease progression, eventually resulting in poorer clinical outcomes, including malignant transformation and death. It is thus crucial to identify these “high-risk” tumors early; this requires an in-depth understanding of the molecular and genetic alterations, thereby providing a theoretical foundation for establishing personalized and precise treatment in the future. Here, we review the most up-to-date knowledge of the cellular biological alterations involved in the progression of meningiomas, including cell proliferation, neo-angiogenesis, inhibition of apoptosis, and immunogenicity. Focused genetic alterations, including chromosomal abnormalities and DNA methylation patterns, are summarized and discussed in detail. We also present latest therapeutic targets and clinical trials for meningiomas' treatment. A further understanding of cellular biological and genetic alterations will provide new prospects for the accurate screening and treatment of recurrent and progressive meningiomas.
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spelling pubmed-91965882022-06-15 Potential Molecular Mechanisms of Recurrent and Progressive Meningiomas: A Review of the Latest Literature Peng, Wenjie Wu, Pei Yuan, Minghao Yuan, Bo Zhu, Lian Zhou, Jiesong Li, Qian Front Oncol Oncology Meningiomas, the most frequent primary intracranial tumors of the central nervous system in adults, originate from the meninges and meningeal spaces. Surgical resection and adjuvant radiation are considered the preferred treatment options. Although most meningiomas are benign and slow-growing, some patients suffer from tumor recurrence and disease progression, eventually resulting in poorer clinical outcomes, including malignant transformation and death. It is thus crucial to identify these “high-risk” tumors early; this requires an in-depth understanding of the molecular and genetic alterations, thereby providing a theoretical foundation for establishing personalized and precise treatment in the future. Here, we review the most up-to-date knowledge of the cellular biological alterations involved in the progression of meningiomas, including cell proliferation, neo-angiogenesis, inhibition of apoptosis, and immunogenicity. Focused genetic alterations, including chromosomal abnormalities and DNA methylation patterns, are summarized and discussed in detail. We also present latest therapeutic targets and clinical trials for meningiomas' treatment. A further understanding of cellular biological and genetic alterations will provide new prospects for the accurate screening and treatment of recurrent and progressive meningiomas. Frontiers Media S.A. 2022-05-30 /pmc/articles/PMC9196588/ /pubmed/35712491 http://dx.doi.org/10.3389/fonc.2022.850463 Text en Copyright © 2022 Peng, Wu, Yuan, Yuan, Zhu, Zhou and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Peng, Wenjie
Wu, Pei
Yuan, Minghao
Yuan, Bo
Zhu, Lian
Zhou, Jiesong
Li, Qian
Potential Molecular Mechanisms of Recurrent and Progressive Meningiomas: A Review of the Latest Literature
title Potential Molecular Mechanisms of Recurrent and Progressive Meningiomas: A Review of the Latest Literature
title_full Potential Molecular Mechanisms of Recurrent and Progressive Meningiomas: A Review of the Latest Literature
title_fullStr Potential Molecular Mechanisms of Recurrent and Progressive Meningiomas: A Review of the Latest Literature
title_full_unstemmed Potential Molecular Mechanisms of Recurrent and Progressive Meningiomas: A Review of the Latest Literature
title_short Potential Molecular Mechanisms of Recurrent and Progressive Meningiomas: A Review of the Latest Literature
title_sort potential molecular mechanisms of recurrent and progressive meningiomas: a review of the latest literature
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9196588/
https://www.ncbi.nlm.nih.gov/pubmed/35712491
http://dx.doi.org/10.3389/fonc.2022.850463
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