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The Potential Value of m6A RNA Methylation in the Development of Cancers Focus on Malignant Glioma
N6-methyladenosine (m6A) RNA methylation is an epigenetic modification that has emerged in the last few years and has received increasing attention as the most abundant internal RNA modification in eukaryotic cells. m6A modifications affect multiple aspects of RNA metabolism, and m6A methylation has...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9196637/ https://www.ncbi.nlm.nih.gov/pubmed/35711459 http://dx.doi.org/10.3389/fimmu.2022.917153 |
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author | Chen, Fan Xie, Xuan Chao, Min Cao, Haiyan Wang, Liang |
author_facet | Chen, Fan Xie, Xuan Chao, Min Cao, Haiyan Wang, Liang |
author_sort | Chen, Fan |
collection | PubMed |
description | N6-methyladenosine (m6A) RNA methylation is an epigenetic modification that has emerged in the last few years and has received increasing attention as the most abundant internal RNA modification in eukaryotic cells. m6A modifications affect multiple aspects of RNA metabolism, and m6A methylation has been shown to play a critical role in the progression of multiple cancers through a variety of mechanisms. This review summarizes the mechanisms by which m6A RNA methylation induced peripheral cancer cell progression and its potential role in the infiltration of immune cell of the glioblastoma microenvironment and novel immunotherapy. Assessing the pattern of m6A modification in glioblastoma will contribute to improving our understanding of microenvironmental infiltration and novel immunotherapies, and help in developing immunotherapeutic strategies. |
format | Online Article Text |
id | pubmed-9196637 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91966372022-06-15 The Potential Value of m6A RNA Methylation in the Development of Cancers Focus on Malignant Glioma Chen, Fan Xie, Xuan Chao, Min Cao, Haiyan Wang, Liang Front Immunol Immunology N6-methyladenosine (m6A) RNA methylation is an epigenetic modification that has emerged in the last few years and has received increasing attention as the most abundant internal RNA modification in eukaryotic cells. m6A modifications affect multiple aspects of RNA metabolism, and m6A methylation has been shown to play a critical role in the progression of multiple cancers through a variety of mechanisms. This review summarizes the mechanisms by which m6A RNA methylation induced peripheral cancer cell progression and its potential role in the infiltration of immune cell of the glioblastoma microenvironment and novel immunotherapy. Assessing the pattern of m6A modification in glioblastoma will contribute to improving our understanding of microenvironmental infiltration and novel immunotherapies, and help in developing immunotherapeutic strategies. Frontiers Media S.A. 2022-05-30 /pmc/articles/PMC9196637/ /pubmed/35711459 http://dx.doi.org/10.3389/fimmu.2022.917153 Text en Copyright © 2022 Chen, Xie, Chao, Cao and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Chen, Fan Xie, Xuan Chao, Min Cao, Haiyan Wang, Liang The Potential Value of m6A RNA Methylation in the Development of Cancers Focus on Malignant Glioma |
title | The Potential Value of m6A RNA Methylation in the Development of Cancers Focus on Malignant Glioma |
title_full | The Potential Value of m6A RNA Methylation in the Development of Cancers Focus on Malignant Glioma |
title_fullStr | The Potential Value of m6A RNA Methylation in the Development of Cancers Focus on Malignant Glioma |
title_full_unstemmed | The Potential Value of m6A RNA Methylation in the Development of Cancers Focus on Malignant Glioma |
title_short | The Potential Value of m6A RNA Methylation in the Development of Cancers Focus on Malignant Glioma |
title_sort | potential value of m6a rna methylation in the development of cancers focus on malignant glioma |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9196637/ https://www.ncbi.nlm.nih.gov/pubmed/35711459 http://dx.doi.org/10.3389/fimmu.2022.917153 |
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