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The Potential Value of m6A RNA Methylation in the Development of Cancers Focus on Malignant Glioma

N6-methyladenosine (m6A) RNA methylation is an epigenetic modification that has emerged in the last few years and has received increasing attention as the most abundant internal RNA modification in eukaryotic cells. m6A modifications affect multiple aspects of RNA metabolism, and m6A methylation has...

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Detalles Bibliográficos
Autores principales: Chen, Fan, Xie, Xuan, Chao, Min, Cao, Haiyan, Wang, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9196637/
https://www.ncbi.nlm.nih.gov/pubmed/35711459
http://dx.doi.org/10.3389/fimmu.2022.917153
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author Chen, Fan
Xie, Xuan
Chao, Min
Cao, Haiyan
Wang, Liang
author_facet Chen, Fan
Xie, Xuan
Chao, Min
Cao, Haiyan
Wang, Liang
author_sort Chen, Fan
collection PubMed
description N6-methyladenosine (m6A) RNA methylation is an epigenetic modification that has emerged in the last few years and has received increasing attention as the most abundant internal RNA modification in eukaryotic cells. m6A modifications affect multiple aspects of RNA metabolism, and m6A methylation has been shown to play a critical role in the progression of multiple cancers through a variety of mechanisms. This review summarizes the mechanisms by which m6A RNA methylation induced peripheral cancer cell progression and its potential role in the infiltration of immune cell of the glioblastoma microenvironment and novel immunotherapy. Assessing the pattern of m6A modification in glioblastoma will contribute to improving our understanding of microenvironmental infiltration and novel immunotherapies, and help in developing immunotherapeutic strategies.
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spelling pubmed-91966372022-06-15 The Potential Value of m6A RNA Methylation in the Development of Cancers Focus on Malignant Glioma Chen, Fan Xie, Xuan Chao, Min Cao, Haiyan Wang, Liang Front Immunol Immunology N6-methyladenosine (m6A) RNA methylation is an epigenetic modification that has emerged in the last few years and has received increasing attention as the most abundant internal RNA modification in eukaryotic cells. m6A modifications affect multiple aspects of RNA metabolism, and m6A methylation has been shown to play a critical role in the progression of multiple cancers through a variety of mechanisms. This review summarizes the mechanisms by which m6A RNA methylation induced peripheral cancer cell progression and its potential role in the infiltration of immune cell of the glioblastoma microenvironment and novel immunotherapy. Assessing the pattern of m6A modification in glioblastoma will contribute to improving our understanding of microenvironmental infiltration and novel immunotherapies, and help in developing immunotherapeutic strategies. Frontiers Media S.A. 2022-05-30 /pmc/articles/PMC9196637/ /pubmed/35711459 http://dx.doi.org/10.3389/fimmu.2022.917153 Text en Copyright © 2022 Chen, Xie, Chao, Cao and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Chen, Fan
Xie, Xuan
Chao, Min
Cao, Haiyan
Wang, Liang
The Potential Value of m6A RNA Methylation in the Development of Cancers Focus on Malignant Glioma
title The Potential Value of m6A RNA Methylation in the Development of Cancers Focus on Malignant Glioma
title_full The Potential Value of m6A RNA Methylation in the Development of Cancers Focus on Malignant Glioma
title_fullStr The Potential Value of m6A RNA Methylation in the Development of Cancers Focus on Malignant Glioma
title_full_unstemmed The Potential Value of m6A RNA Methylation in the Development of Cancers Focus on Malignant Glioma
title_short The Potential Value of m6A RNA Methylation in the Development of Cancers Focus on Malignant Glioma
title_sort potential value of m6a rna methylation in the development of cancers focus on malignant glioma
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9196637/
https://www.ncbi.nlm.nih.gov/pubmed/35711459
http://dx.doi.org/10.3389/fimmu.2022.917153
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