Selective Vulnerability of Senescent Glioblastoma Cells to BCL-XL Inhibition

Glioblastoma (GBM) is a rapidly fatal malignancy typically treated with radiation and temozolomide (TMZ), an alkylating chemotherapeutic. These cytotoxic therapies cause oxidative stress and DNA damage, yielding a senescent-like state of replicative arrest in surviving tumor cells. Unfortunately, re...

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Detalles Bibliográficos
Autores principales: Rahman, Masum, Olson, Ian, Mansour, Moustafa, Carlstrom, Lucas P., Sutiwisesak, Rujapope, Saber, Rehan, Rajani, Karishma, Warrington, Arthur E., Howard, Adam, Schroeder, Mark, Chen, Sisi, Decker, Paul A., Sananikone, Eliot F., Zhu, Yi, Tchkonia, Tamar, Parney, Ian F., Burma, Sandeep, Brown, Desmond, Rodriguez, Moses, Sarkaria, Jann N., Kirkland, James L., Burns, Terry C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
New Horizons in Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9196639/
https://www.ncbi.nlm.nih.gov/pubmed/35191501
http://dx.doi.org/10.1158/1541-7786.MCR-21-0029

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