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Waning effectiveness of SARS-CoV-2 mRNA vaccines in older adults: a rapid review
The U.S. Centers for Disease Control and Prevention (CDC) and other health agencies have recently recommended a booster dose of COVID-19 vaccines for specific vulnerable groups including adults 65 years and older. There is limited evidence whether vaccine effectiveness (VE) in older adults decreases...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9196671/ https://www.ncbi.nlm.nih.gov/pubmed/35240940 http://dx.doi.org/10.1080/21645515.2022.2045857 |
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author | Nanishi, Etsuro Levy, Ofer Ozonoff, Al |
author_facet | Nanishi, Etsuro Levy, Ofer Ozonoff, Al |
author_sort | Nanishi, Etsuro |
collection | PubMed |
description | The U.S. Centers for Disease Control and Prevention (CDC) and other health agencies have recently recommended a booster dose of COVID-19 vaccines for specific vulnerable groups including adults 65 years and older. There is limited evidence whether vaccine effectiveness (VE) in older adults decreases over time, especially against severe COVID-19. We performed a rapid review of published studies available through 4 November 2021 that provide effectiveness data on messenger RNA (mRNA) vaccines approved/licensed in the United States and identified eight eligible studies which evaluated VE in older adults. There is evidence of a decline in VE against both severe acute respiratory syndrome coronavirus 2 infection and severe COVID-19 in older adults among studies which analyzed data up to July–October 2021. Our findings suggest that VE diminishes in older adults, which supports the current recommendation for a booster dose in this population. |
format | Online Article Text |
id | pubmed-9196671 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-91966712022-06-15 Waning effectiveness of SARS-CoV-2 mRNA vaccines in older adults: a rapid review Nanishi, Etsuro Levy, Ofer Ozonoff, Al Hum Vaccin Immunother Coronavirus – Mini-Review The U.S. Centers for Disease Control and Prevention (CDC) and other health agencies have recently recommended a booster dose of COVID-19 vaccines for specific vulnerable groups including adults 65 years and older. There is limited evidence whether vaccine effectiveness (VE) in older adults decreases over time, especially against severe COVID-19. We performed a rapid review of published studies available through 4 November 2021 that provide effectiveness data on messenger RNA (mRNA) vaccines approved/licensed in the United States and identified eight eligible studies which evaluated VE in older adults. There is evidence of a decline in VE against both severe acute respiratory syndrome coronavirus 2 infection and severe COVID-19 in older adults among studies which analyzed data up to July–October 2021. Our findings suggest that VE diminishes in older adults, which supports the current recommendation for a booster dose in this population. Taylor & Francis 2022-03-03 /pmc/articles/PMC9196671/ /pubmed/35240940 http://dx.doi.org/10.1080/21645515.2022.2045857 Text en © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
spellingShingle | Coronavirus – Mini-Review Nanishi, Etsuro Levy, Ofer Ozonoff, Al Waning effectiveness of SARS-CoV-2 mRNA vaccines in older adults: a rapid review |
title | Waning effectiveness of SARS-CoV-2 mRNA vaccines in older adults: a rapid review |
title_full | Waning effectiveness of SARS-CoV-2 mRNA vaccines in older adults: a rapid review |
title_fullStr | Waning effectiveness of SARS-CoV-2 mRNA vaccines in older adults: a rapid review |
title_full_unstemmed | Waning effectiveness of SARS-CoV-2 mRNA vaccines in older adults: a rapid review |
title_short | Waning effectiveness of SARS-CoV-2 mRNA vaccines in older adults: a rapid review |
title_sort | waning effectiveness of sars-cov-2 mrna vaccines in older adults: a rapid review |
topic | Coronavirus – Mini-Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9196671/ https://www.ncbi.nlm.nih.gov/pubmed/35240940 http://dx.doi.org/10.1080/21645515.2022.2045857 |
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