Intratumoural administration of an NKT cell agonist with CpG promotes NKT cell infiltration associated with an enhanced antitumour response and abscopal effect

Intratumoural administration of unmethylated cytosine-phosphate-guanine motifs (CpG) to stimulate toll-like receptor (TLR)-9 has been shown to induce tumour regression in preclinical studies and some efficacy in the clinic. Because activated natural killer T (NKT) cells can cooperate with pattern-re...

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Detalles Bibliográficos
Autores principales: Prasit, Kef K, Ferrer-Font, Laura, Burn, Olivia K, Anderson, Regan J, Compton, Benjamin J, Schmidt, Alfonso J, Mayer, Johannes U, Chen, Chun-Jen J, Dasyam, Nathaniel, Ritchie, David S, Godfrey, Dale I, Mattarollo, Stephen R, Dunbar, P Rod, Painter, Gavin F, Hermans, Ian F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9196710/
https://www.ncbi.nlm.nih.gov/pubmed/35712122
http://dx.doi.org/10.1080/2162402X.2022.2081009

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