LGALS3 (galectin 3) mediates an unconventional secretion of SNCA/α-synuclein in response to lysosomal membrane damage by the autophagic-lysosomal pathway in human midbrain dopamine neurons

Numerous lines of evidence support the premise that the misfolding and subsequent accumulation of SNCA/α-synuclein (synuclein alpha) is responsible for the underlying neuronal pathology observed in Parkinson disease (PD) and other synucleinopathies. Moreover, the cell-to-cell transfer of these misfo...

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Detalles Bibliográficos
Autores principales: Burbidge, Kevin, Rademacher, David J., Mattick, Jessica, Zack, Stephanie, Grillini, Andrea, Bousset, Luc, Kwon, Ochan, Kubicki, Konrad, Simon, Alexander, Melki, Ronald, Campbell, Edward M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9196737/
https://www.ncbi.nlm.nih.gov/pubmed/34612142
http://dx.doi.org/10.1080/15548627.2021.1967615

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