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ALS/FTD: Evolution, Aging, and Cellular Metabolic Exhaustion
Amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD) are neurodegenerations with evolutionary underpinnings, expansive clinical presentations, and multiple genetic risk factors involving a complex network of pathways. This perspective considers the complex cellular pathology of aging...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9196861/ https://www.ncbi.nlm.nih.gov/pubmed/35711269 http://dx.doi.org/10.3389/fneur.2022.890203 |
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author | Henderson, Robert David Kepp, Kasper Planeta Eisen, Andrew |
author_facet | Henderson, Robert David Kepp, Kasper Planeta Eisen, Andrew |
author_sort | Henderson, Robert David |
collection | PubMed |
description | Amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD) are neurodegenerations with evolutionary underpinnings, expansive clinical presentations, and multiple genetic risk factors involving a complex network of pathways. This perspective considers the complex cellular pathology of aging motoneuronal and frontal/prefrontal cortical networks in the context of evolutionary, clinical, and biochemical features of the disease. We emphasize the importance of evolution in the development of the higher cortical function, within the influence of increasing lifespan. Particularly, the role of aging on the metabolic competence of delicately optimized neurons, age-related increased proteostatic costs, and specific genetic risk factors that gradually reduce the energy available for neuronal function leading to neuronal failure and disease. |
format | Online Article Text |
id | pubmed-9196861 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91968612022-06-15 ALS/FTD: Evolution, Aging, and Cellular Metabolic Exhaustion Henderson, Robert David Kepp, Kasper Planeta Eisen, Andrew Front Neurol Neurology Amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD) are neurodegenerations with evolutionary underpinnings, expansive clinical presentations, and multiple genetic risk factors involving a complex network of pathways. This perspective considers the complex cellular pathology of aging motoneuronal and frontal/prefrontal cortical networks in the context of evolutionary, clinical, and biochemical features of the disease. We emphasize the importance of evolution in the development of the higher cortical function, within the influence of increasing lifespan. Particularly, the role of aging on the metabolic competence of delicately optimized neurons, age-related increased proteostatic costs, and specific genetic risk factors that gradually reduce the energy available for neuronal function leading to neuronal failure and disease. Frontiers Media S.A. 2022-05-27 /pmc/articles/PMC9196861/ /pubmed/35711269 http://dx.doi.org/10.3389/fneur.2022.890203 Text en Copyright © 2022 Henderson, Kepp and Eisen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Henderson, Robert David Kepp, Kasper Planeta Eisen, Andrew ALS/FTD: Evolution, Aging, and Cellular Metabolic Exhaustion |
title | ALS/FTD: Evolution, Aging, and Cellular Metabolic Exhaustion |
title_full | ALS/FTD: Evolution, Aging, and Cellular Metabolic Exhaustion |
title_fullStr | ALS/FTD: Evolution, Aging, and Cellular Metabolic Exhaustion |
title_full_unstemmed | ALS/FTD: Evolution, Aging, and Cellular Metabolic Exhaustion |
title_short | ALS/FTD: Evolution, Aging, and Cellular Metabolic Exhaustion |
title_sort | als/ftd: evolution, aging, and cellular metabolic exhaustion |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9196861/ https://www.ncbi.nlm.nih.gov/pubmed/35711269 http://dx.doi.org/10.3389/fneur.2022.890203 |
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