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An Isogenic Collection of Pluripotent Stem Cell Lines With Elevated α-Synuclein Expression Validated for Neural Induction and Cortical Neuron Differentiation

α-Synuclein (αSyn) is a small, disordered protein that becomes aggregated in Lewy body diseases, such as Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). Human induced pluripotent stem cells (hiPSCs) potentially provide a tractable disease model to monitor early molecular changes associ...

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Detalles Bibliográficos
Autores principales:	Natalwala, Ammar, Behbehani, Ranya, Yapom, Ratsuda, Kunath, Tilo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9196909/ https://www.ncbi.nlm.nih.gov/pubmed/35712660 http://dx.doi.org/10.3389/fcell.2022.898560

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