Cargando…

Acyl-Hydrazide Derivatives of a Xanthine Carboxylic Congener (XCC) as Selective Antagonists at Human A(2B) Adenosine Receptors

The structure–activity relationships (SAR) of 8-phenyl-1,3-dipropylxanthine derivatives in binding to recombinant human A(2B) adenosine receptors were explored, in order to identify selective antagonists. Based on the finding of receptor selectivity in MRS 1204, containing an N-hydroxysuccinimide es...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Yong-Chul, Karton, Yishai, Ji, Xiao-duo, Melman, Neli, Linden, Joel, Jacobson, Kenneth A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	1999
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9196953/ https://www.ncbi.nlm.nih.gov/pubmed/35790094 http://dx.doi.org/10.1002/(sici)1098-2299(199908)47:4<178::aid-ddr4>3.0.co;2-l

Ejemplares similares

Acyl Hydrazides and Acyl Hydrazones as High-Performance Chemical Exchange Saturation Transfer MRI Contrast Agents
por: Bo, Shaowei, et al.
Publicado: (2023)

Adenosine Amine Congener as a Cochlear Rescue Agent
por: Vlajkovic, Srdjan M., et al.
Publicado: (2014)

Formation of Synthetically Versatile 2-Aminobenzophenones from Readily Accessed Acyl Hydrazides
por: Ahmed, Nehaal, et al.
Publicado: (2019)

Adenosine Deaminase, Nucleoside Phosphorylase and Xanthine Oxidase in Liver Tumours
por: Reid, E., et al.
Publicado: (1957)

Structure of apo flavin-dependent halogenase Xcc4156 hints at a reason for cofactor-soaking difficulties
por: Widmann, Christiane, et al.
Publicado: (2020)

HprK(Xcc) is a serine kinase that regulates virulence in the Gram‐negative phytopathogen Xanthomonas campestris
por: Li, Rui‐Fang, et al.
Publicado: (2019)

Structural Probing of Off-Target G Protein-Coupled Receptor Activities within a Series of Adenosine/Adenine Congeners
por: Paoletta, Silvia, et al.
Publicado: (2014)

Synthesis, Carbonic Anhydrase II/IX/XII Inhibition, DFT, and Molecular Docking Studies of Hydrazide-Sulfonamide Hybrids of 4-Methylsalicyl- and Acyl-Substituted Hydrazide
por: Khushal, Adil, et al.
Publicado: (2022)

Kinetic study on the inhibition of xanthine oxidase by acylated derivatives of flavonoids synthesised enzymatically
por: de Araújo, Maria Elisa Melo Branco, et al.
Publicado: (2017)

Kinetic profiling and functional characterization of 8-phenylxanthine derivatives as A(2B) adenosine receptor antagonists
por: Vlachodimou, Anna, et al.
Publicado: (2022)

Antiplatelet Effects of Selected Xanthine-Based Adenosine A(2A) and A(2B) Receptor Antagonists Determined in Rat Blood
por: Kubacka, Monika, et al.
Publicado: (2023)

Application of the functionalized congener approach to dendrimer-based signaling agents acting through A(2A) adenosine receptors
por: Kim, Yoonkyung, et al.
Publicado: (2008)

Synthesis, Characterization, and Biologic Activity of New Acyl Hydrazides and 1,3,4-Oxadiazole Derivatives
por: Zarafu, Irina, et al.
Publicado: (2020)

Inheritance of Black Rot Resistance and Development of Molecular Marker Linked to Xcc Races 6 and 7 Resistance in Cabbage
por: Hong, Jeong-Eui, et al.
Publicado: (2021)

Pharmacokinetic Properties of Adenosine Amine Congener in Cochlear Perilymph after Systemic Administration
por: Chang, Hao, et al.
Publicado: (2017)

Bitopic fluorescent antagonists of the A(2A) adenosine receptor based on pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine functionalized congeners
por: Duroux, Romain, et al.
Publicado: (2017)

A convergent synthesis of 1,3,4-oxadiazoles from acyl hydrazides under semiaqueous conditions
por: Tokumaru, Kazuyuki, et al.
Publicado: (2017)

Probing Substituents in the 1- and 3-Position: Tetrahydropyrazino-Annelated Water-Soluble Xanthine Derivatives as Multi-Target Drugs With Potent Adenosine Receptor Antagonistic Activity
por: Koch, Pierre, et al.
Publicado: (2018)

Arabidopsis HFR1 Is a Potential Nuclear Substrate Regulated by the Xanthomonas Type III Effector XopD(Xcc8004)
por: Tan, Choon Meng, et al.
Publicado: (2015)

Determination of serum adenosine deaminase and xanthine oxidase activity in Kangal dogs with maternal cannibalism
por: Ercan, N., et al.
Publicado: (2017)

Species Differences in Microsomal Metabolism of Xanthine-Derived A(1) Adenosine Receptor Ligands
por: Schneider, Daniela, et al.
Publicado: (2021)

3-Dialkylamino-1,2,4-triazoles via Zn(II)-Catalyzed Acyl Hydrazide–Dialkylcyanamide Coupling
por: Yunusova, Sevilya N., et al.
Publicado: (2018)

The N’-Substituted Derivatives of 5-Chloro-3-Methylisothiazole-4-Carboxylic Acid Hydrazide with Antiproliferative Activity
por: Jęśkowiak, Izabela, et al.
Publicado: (2019)

Xanthine urolithiasis: Inhibitors of xanthine crystallization
por: Grases, Felix, et al.
Publicado: (2018)

Determination of Serum Adenosine Deaminase and Xanthine Oxidase Levels in Patients with Crimean–Congo Hemorrhagic Fever
por: Celik, V. Kenan, et al.
Publicado: (2010)

Anti-Hyperuricemic Effects of Astaxanthin by Regulating Xanthine Oxidase, Adenosine Deaminase and Urate Transporters in Rats
por: Le, Yanzuo, et al.
Publicado: (2020)

Diffusible signal factor primes plant immunity against Xanthomonas campestris pv. campestris (Xcc) via JA signaling in Arabidopsis and Brassica oleracea
por: Zhao, Qian, et al.
Publicado: (2023)

Isonicotinic Acid Hydrazide
Publicado: (1952)

Introducing Lipophilicity to (Polyhydroxyalkyl)thiazolidine Carboxylic Acids Via Acylation
por: Novo Fernández, Olalla, et al.
Publicado: (2022)

Synthesis of Novel Fluorinated Xanthine Derivatives with High Adenosine A(2B) Receptor Binding Affinity
por: Lindemann, Marcel, et al.
Publicado: (2021)

Models for Antitubercular Activity of 5′-O-[(N-Acyl)sulfamoyl]adenosines
por: Goyal, Rakesh K., et al.
Publicado: (2010)

Biological Evaluation and Docking Studies of New Carbamate, Thiocarbamate, and Hydrazide Analogues of Acyl Homoserine Lactones as Vibrio fischeri-Quorum Sensing Modulators
por: Zhang, Qiang, et al.
Publicado: (2020)

N′-Cyclopentylidenepyridine-4-carbohydrazide
por: Lemmerer, Andreas, et al.
Publicado: (2012)

Effect of Adenosine Receptor Antagonists on Adenosine-Pretreated PC12 Cells Exposed to Paraquat
por: Shang, Liangcheng, et al.
Publicado: (2022)

Exploration of Novel Xanthine Oxidase Inhibitors Based on 1,6-Dihydropyrimidine-5-Carboxylic Acids by an Integrated in Silico Study
por: Zhai, Na, et al.
Publicado: (2021)

Limits of Ligand Selectivity from Docking to Models: In Silico Screening for A(1) Adenosine Receptor Antagonists
por: Kolb, Peter, et al.
Publicado: (2012)

Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists
por: Tosh, Dilip K., et al.
Publicado: (2018)

Irreversible Antagonists for the Adenosine A(2B) Receptor †
por: Temirak, Ahmed, et al.
Publicado: (2022)

Adenosine-Related Mechanisms in Non-Adenosine Receptor Drugs
por: Jacobson, Kenneth A., et al.
Publicado: (2020)

Acyl Radicals from Aromatic Carboxylic Acids by Means of Visible-Light Photoredox Catalysis
por: Bergonzini, Giulia, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_a8tpe4prirsp0g0lekoemoimvc