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Effectiveness of Response Inhibition Training and Its Long-Term Effects in Healthy Adults: A Systematic Review and Meta-Analysis
OBJECTIVE: This study aims to evaluate the effectiveness and long-term effects of response inhibition training as a therapeutic approach in healthy adults. METHODS: The PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang, and China Science and Technology Journal D...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197126/ https://www.ncbi.nlm.nih.gov/pubmed/35712455 http://dx.doi.org/10.3389/fnins.2022.813975 |
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author | Li, Wanyue Shang, Yaru Zhuang, Weisheng Mai, Wangxiang Cheng, Wenwen Chen, Zhuoming |
author_facet | Li, Wanyue Shang, Yaru Zhuang, Weisheng Mai, Wangxiang Cheng, Wenwen Chen, Zhuoming |
author_sort | Li, Wanyue |
collection | PubMed |
description | OBJECTIVE: This study aims to evaluate the effectiveness and long-term effects of response inhibition training as a therapeutic approach in healthy adults. METHODS: The PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang, and China Science and Technology Journal Database (VIP) were searched for studies. Data on the improvement of Cognitive function and its long-term effect were extracted by two authors independently. The pooled data were meta-analyzed using a random-effects model, and the quality of each eligible study was assessed by The Cochrane Collaboration’s tool. RESULTS: Nine articles were included. 1 of the articles included 2 trials, so 10 eligible trials (response inhibition training group vs. control group) were identified. A total of 490 patients were included. Response inhibition training has beneficial effects on improving cognitive function in healthy adults compared to control treatment (SMD, −0.93; 95% CI, −1.56 to −0.30; Z = 2.88, P = 0.004), the subgroup analysis results showed that either GNG training alone (SMD, −2.27; 95% CI, −3.33 to −1.21; Z = 4.18, P < 0.0001) or the combination of both SST and GNG significantly improved cognitive function in healthy adults (SMD, −0.94; 95% CI, −1.33 to −0.56; Z = 4.80, P < 0.0001), whereas SST training alone did not have such an effect (SMD, −0.15; 95% CI, −0.76 to 0.47; Z = 0.47, P = 0.64). But its long-term effects are not significant (SMD, −0.29; 95% CI, −0.68 to 0.10; Z = 1.45, P = 0.15). The subgroup analysis results showed that neither GNG training alone (SMD, −0.25; 95% CI, −0.75 to 0.24; Z = 0.99, P = 0.32) nor SST training alone (SMD, 0.03; 95% CI, −0.42 to 0.48; Z = 0.14, P = 0.89) could improve the cognitive function of healthy adults in the long term. In contrast, the combination of both training (SMD, −0.95; 95% CI, −1.46 to −0.45; Z = 3.68, P = 0.0002) can have long-term effects on the improvement of cognitive function in healthy adults. CONCLUSION: The findings of our study indicate that response inhibition training can improve the cognitive function of healthy adults and that more RCTs need to be conducted to validate their usefulness in clinical cases. |
format | Online Article Text |
id | pubmed-9197126 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91971262022-06-15 Effectiveness of Response Inhibition Training and Its Long-Term Effects in Healthy Adults: A Systematic Review and Meta-Analysis Li, Wanyue Shang, Yaru Zhuang, Weisheng Mai, Wangxiang Cheng, Wenwen Chen, Zhuoming Front Neurosci Neuroscience OBJECTIVE: This study aims to evaluate the effectiveness and long-term effects of response inhibition training as a therapeutic approach in healthy adults. METHODS: The PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang, and China Science and Technology Journal Database (VIP) were searched for studies. Data on the improvement of Cognitive function and its long-term effect were extracted by two authors independently. The pooled data were meta-analyzed using a random-effects model, and the quality of each eligible study was assessed by The Cochrane Collaboration’s tool. RESULTS: Nine articles were included. 1 of the articles included 2 trials, so 10 eligible trials (response inhibition training group vs. control group) were identified. A total of 490 patients were included. Response inhibition training has beneficial effects on improving cognitive function in healthy adults compared to control treatment (SMD, −0.93; 95% CI, −1.56 to −0.30; Z = 2.88, P = 0.004), the subgroup analysis results showed that either GNG training alone (SMD, −2.27; 95% CI, −3.33 to −1.21; Z = 4.18, P < 0.0001) or the combination of both SST and GNG significantly improved cognitive function in healthy adults (SMD, −0.94; 95% CI, −1.33 to −0.56; Z = 4.80, P < 0.0001), whereas SST training alone did not have such an effect (SMD, −0.15; 95% CI, −0.76 to 0.47; Z = 0.47, P = 0.64). But its long-term effects are not significant (SMD, −0.29; 95% CI, −0.68 to 0.10; Z = 1.45, P = 0.15). The subgroup analysis results showed that neither GNG training alone (SMD, −0.25; 95% CI, −0.75 to 0.24; Z = 0.99, P = 0.32) nor SST training alone (SMD, 0.03; 95% CI, −0.42 to 0.48; Z = 0.14, P = 0.89) could improve the cognitive function of healthy adults in the long term. In contrast, the combination of both training (SMD, −0.95; 95% CI, −1.46 to −0.45; Z = 3.68, P = 0.0002) can have long-term effects on the improvement of cognitive function in healthy adults. CONCLUSION: The findings of our study indicate that response inhibition training can improve the cognitive function of healthy adults and that more RCTs need to be conducted to validate their usefulness in clinical cases. Frontiers Media S.A. 2022-05-30 /pmc/articles/PMC9197126/ /pubmed/35712455 http://dx.doi.org/10.3389/fnins.2022.813975 Text en Copyright © 2022 Li, Shang, Zhuang, Mai, Cheng and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Li, Wanyue Shang, Yaru Zhuang, Weisheng Mai, Wangxiang Cheng, Wenwen Chen, Zhuoming Effectiveness of Response Inhibition Training and Its Long-Term Effects in Healthy Adults: A Systematic Review and Meta-Analysis |
title | Effectiveness of Response Inhibition Training and Its Long-Term Effects in Healthy Adults: A Systematic Review and Meta-Analysis |
title_full | Effectiveness of Response Inhibition Training and Its Long-Term Effects in Healthy Adults: A Systematic Review and Meta-Analysis |
title_fullStr | Effectiveness of Response Inhibition Training and Its Long-Term Effects in Healthy Adults: A Systematic Review and Meta-Analysis |
title_full_unstemmed | Effectiveness of Response Inhibition Training and Its Long-Term Effects in Healthy Adults: A Systematic Review and Meta-Analysis |
title_short | Effectiveness of Response Inhibition Training and Its Long-Term Effects in Healthy Adults: A Systematic Review and Meta-Analysis |
title_sort | effectiveness of response inhibition training and its long-term effects in healthy adults: a systematic review and meta-analysis |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197126/ https://www.ncbi.nlm.nih.gov/pubmed/35712455 http://dx.doi.org/10.3389/fnins.2022.813975 |
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