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Recent Trends in Composite Nanozymes and Their Pro-Oxidative Role in Therapeutics

Nanozymes are inorganic nanostructures whose enzyme mimic activities are increasingly explored in disease treatment, taking inspiration from natural enzymes. The catalytic ability of nanozymes to generate reactive oxygen species can be used for designing effective antimicrobials and antitumor therap...

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Detalles Bibliográficos
Autores principales: Maddheshiya, Shilpa, Nara, Seema
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197165/
https://www.ncbi.nlm.nih.gov/pubmed/35711631
http://dx.doi.org/10.3389/fbioe.2022.880214
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author Maddheshiya, Shilpa
Nara, Seema
author_facet Maddheshiya, Shilpa
Nara, Seema
author_sort Maddheshiya, Shilpa
collection PubMed
description Nanozymes are inorganic nanostructures whose enzyme mimic activities are increasingly explored in disease treatment, taking inspiration from natural enzymes. The catalytic ability of nanozymes to generate reactive oxygen species can be used for designing effective antimicrobials and antitumor therapeutics. In this context, composite nanozymes are advantageous, particularly because they integrate the properties of various nanomaterials to offer a single multifunctional platform combining photodynamic therapy (PDT), photothermal therapy (PTT), and chemodynamic therapy (CDT). Hence, recent years have witnessed great progress in engineering composite nanozymes for enhanced pro-oxidative activity that can be utilized in therapeutics. Therefore, the present review traverses over the newer strategies to design composite nanozymes as pro-oxidative therapeutics. It provides recent trends in the use of composite nanozymes as antibacterial, antibiofilm, and antitumor agents. This review also analyzes various challenges yet to be overcome by pro-oxidative composite nanozymes before being used in the field.
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spelling pubmed-91971652022-06-15 Recent Trends in Composite Nanozymes and Their Pro-Oxidative Role in Therapeutics Maddheshiya, Shilpa Nara, Seema Front Bioeng Biotechnol Bioengineering and Biotechnology Nanozymes are inorganic nanostructures whose enzyme mimic activities are increasingly explored in disease treatment, taking inspiration from natural enzymes. The catalytic ability of nanozymes to generate reactive oxygen species can be used for designing effective antimicrobials and antitumor therapeutics. In this context, composite nanozymes are advantageous, particularly because they integrate the properties of various nanomaterials to offer a single multifunctional platform combining photodynamic therapy (PDT), photothermal therapy (PTT), and chemodynamic therapy (CDT). Hence, recent years have witnessed great progress in engineering composite nanozymes for enhanced pro-oxidative activity that can be utilized in therapeutics. Therefore, the present review traverses over the newer strategies to design composite nanozymes as pro-oxidative therapeutics. It provides recent trends in the use of composite nanozymes as antibacterial, antibiofilm, and antitumor agents. This review also analyzes various challenges yet to be overcome by pro-oxidative composite nanozymes before being used in the field. Frontiers Media S.A. 2022-05-30 /pmc/articles/PMC9197165/ /pubmed/35711631 http://dx.doi.org/10.3389/fbioe.2022.880214 Text en Copyright © 2022 Maddheshiya and Nara. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Maddheshiya, Shilpa
Nara, Seema
Recent Trends in Composite Nanozymes and Their Pro-Oxidative Role in Therapeutics
title Recent Trends in Composite Nanozymes and Their Pro-Oxidative Role in Therapeutics
title_full Recent Trends in Composite Nanozymes and Their Pro-Oxidative Role in Therapeutics
title_fullStr Recent Trends in Composite Nanozymes and Their Pro-Oxidative Role in Therapeutics
title_full_unstemmed Recent Trends in Composite Nanozymes and Their Pro-Oxidative Role in Therapeutics
title_short Recent Trends in Composite Nanozymes and Their Pro-Oxidative Role in Therapeutics
title_sort recent trends in composite nanozymes and their pro-oxidative role in therapeutics
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197165/
https://www.ncbi.nlm.nih.gov/pubmed/35711631
http://dx.doi.org/10.3389/fbioe.2022.880214
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