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Admission Levels of Serum P-Selectin and IL-6 Can Predict Development of Deep Venous Thrombosis in Hospitalized Covid-19 Patients

BACKGROUND AND AIM: Deep venous thrombosis (DVT) of the lower extremities is common in Covid-19 patients. Interleukin (IL)-6 and P-selectin were found to be elevated in Covid-19 patients. The current study aimed to evaluate P-selectin and IL6 in Covid-19 patients with DVT and to explore its relation...

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Autores principales: Farouk, Nehal, Ashry, Walaa Mohamed Omar, EL-Hagrasy, Hanan A, Mohamed, Eman F, Eltrawy, Heba H, El-Nasser, Asmaa M, Shipl, Walaa, Attar, Shahinaz El, Kh Sakr, Lobna, Abdel Wahab, Maisa A, Abdelsalam, Eman M, Sharaf, Fawzia A, Ahmad, Inass Hassan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197170/
https://www.ncbi.nlm.nih.gov/pubmed/35712059
http://dx.doi.org/10.2147/IJGM.S357097
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author Farouk, Nehal
Ashry, Walaa Mohamed Omar
EL-Hagrasy, Hanan A
Mohamed, Eman F
Eltrawy, Heba H
El-Nasser, Asmaa M
Shipl, Walaa
Attar, Shahinaz El
Kh Sakr, Lobna
Abdel Wahab, Maisa A
Abdelsalam, Eman M
Sharaf, Fawzia A
Ahmad, Inass Hassan
author_facet Farouk, Nehal
Ashry, Walaa Mohamed Omar
EL-Hagrasy, Hanan A
Mohamed, Eman F
Eltrawy, Heba H
El-Nasser, Asmaa M
Shipl, Walaa
Attar, Shahinaz El
Kh Sakr, Lobna
Abdel Wahab, Maisa A
Abdelsalam, Eman M
Sharaf, Fawzia A
Ahmad, Inass Hassan
author_sort Farouk, Nehal
collection PubMed
description BACKGROUND AND AIM: Deep venous thrombosis (DVT) of the lower extremities is common in Covid-19 patients. Interleukin (IL)-6 and P-selectin were found to be elevated in Covid-19 patients. The current study aimed to evaluate P-selectin and IL6 in Covid-19 patients with DVT and to explore its relation to clinical and laboratory parameters in those patients. PATIENTS AND METHODS: The present retrospective study included 150 hospitalized COVID-19 patients diagnosed on the basis of a positive result of reverse-transcriptase polymerase chain reaction (RT-PCR) test. Laboratory assessments were included for IL-6 and P selectin assessments via enzyme-linked immunosorbent assay. The primary outcome of the present study was the development of DVT detected by Doppler ultrasound (DU) evaluation of the lower extremities during the admission. RESULTS: The present study included 150 hospitalized Covid-19 patients. DVT was developed in 59 patients (39.3%). DVP patients had significantly higher levels of P selectin [76.0 (63.0–87.0) versus 63.0 (54.3–75.0), p < 0.001] and IL-6 [37.0 (27.0–49.0) versus 18.5 (13.5–31.5), p < 0.001]. ROC curve analysis revealed good performance of P selectin [AUC (95% CI): 0.72 (0.64–0.81)] and IL-6 [AUC (95% CI): 0.79 (0.71–0.86)] in identification of DVT. Logistic regression analysis identified the presence of severe disease [OR (95% CI): 9.016 (3.61–22.49), p < 0.001], elevated P selectin [OR (95% CI): 1.032 (1.005–1.059), p = 0.018] and elevated IL-6 [OR (95% CI): 1.062 (1.033–1.091), p < 0.001] as significant predictors of DVT development in multivariate analysis. CONCLUSION: The present study identified a probable role of elevated P-selectin and IL-6 levels in the DVT development in hospitalized Covid-19 patients.
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spelling pubmed-91971702022-06-15 Admission Levels of Serum P-Selectin and IL-6 Can Predict Development of Deep Venous Thrombosis in Hospitalized Covid-19 Patients Farouk, Nehal Ashry, Walaa Mohamed Omar EL-Hagrasy, Hanan A Mohamed, Eman F Eltrawy, Heba H El-Nasser, Asmaa M Shipl, Walaa Attar, Shahinaz El Kh Sakr, Lobna Abdel Wahab, Maisa A Abdelsalam, Eman M Sharaf, Fawzia A Ahmad, Inass Hassan Int J Gen Med Original Research BACKGROUND AND AIM: Deep venous thrombosis (DVT) of the lower extremities is common in Covid-19 patients. Interleukin (IL)-6 and P-selectin were found to be elevated in Covid-19 patients. The current study aimed to evaluate P-selectin and IL6 in Covid-19 patients with DVT and to explore its relation to clinical and laboratory parameters in those patients. PATIENTS AND METHODS: The present retrospective study included 150 hospitalized COVID-19 patients diagnosed on the basis of a positive result of reverse-transcriptase polymerase chain reaction (RT-PCR) test. Laboratory assessments were included for IL-6 and P selectin assessments via enzyme-linked immunosorbent assay. The primary outcome of the present study was the development of DVT detected by Doppler ultrasound (DU) evaluation of the lower extremities during the admission. RESULTS: The present study included 150 hospitalized Covid-19 patients. DVT was developed in 59 patients (39.3%). DVP patients had significantly higher levels of P selectin [76.0 (63.0–87.0) versus 63.0 (54.3–75.0), p < 0.001] and IL-6 [37.0 (27.0–49.0) versus 18.5 (13.5–31.5), p < 0.001]. ROC curve analysis revealed good performance of P selectin [AUC (95% CI): 0.72 (0.64–0.81)] and IL-6 [AUC (95% CI): 0.79 (0.71–0.86)] in identification of DVT. Logistic regression analysis identified the presence of severe disease [OR (95% CI): 9.016 (3.61–22.49), p < 0.001], elevated P selectin [OR (95% CI): 1.032 (1.005–1.059), p = 0.018] and elevated IL-6 [OR (95% CI): 1.062 (1.033–1.091), p < 0.001] as significant predictors of DVT development in multivariate analysis. CONCLUSION: The present study identified a probable role of elevated P-selectin and IL-6 levels in the DVT development in hospitalized Covid-19 patients. Dove 2022-06-10 /pmc/articles/PMC9197170/ /pubmed/35712059 http://dx.doi.org/10.2147/IJGM.S357097 Text en © 2022 Farouk et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Farouk, Nehal
Ashry, Walaa Mohamed Omar
EL-Hagrasy, Hanan A
Mohamed, Eman F
Eltrawy, Heba H
El-Nasser, Asmaa M
Shipl, Walaa
Attar, Shahinaz El
Kh Sakr, Lobna
Abdel Wahab, Maisa A
Abdelsalam, Eman M
Sharaf, Fawzia A
Ahmad, Inass Hassan
Admission Levels of Serum P-Selectin and IL-6 Can Predict Development of Deep Venous Thrombosis in Hospitalized Covid-19 Patients
title Admission Levels of Serum P-Selectin and IL-6 Can Predict Development of Deep Venous Thrombosis in Hospitalized Covid-19 Patients
title_full Admission Levels of Serum P-Selectin and IL-6 Can Predict Development of Deep Venous Thrombosis in Hospitalized Covid-19 Patients
title_fullStr Admission Levels of Serum P-Selectin and IL-6 Can Predict Development of Deep Venous Thrombosis in Hospitalized Covid-19 Patients
title_full_unstemmed Admission Levels of Serum P-Selectin and IL-6 Can Predict Development of Deep Venous Thrombosis in Hospitalized Covid-19 Patients
title_short Admission Levels of Serum P-Selectin and IL-6 Can Predict Development of Deep Venous Thrombosis in Hospitalized Covid-19 Patients
title_sort admission levels of serum p-selectin and il-6 can predict development of deep venous thrombosis in hospitalized covid-19 patients
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197170/
https://www.ncbi.nlm.nih.gov/pubmed/35712059
http://dx.doi.org/10.2147/IJGM.S357097
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