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Admission Levels of Serum P-Selectin and IL-6 Can Predict Development of Deep Venous Thrombosis in Hospitalized Covid-19 Patients
BACKGROUND AND AIM: Deep venous thrombosis (DVT) of the lower extremities is common in Covid-19 patients. Interleukin (IL)-6 and P-selectin were found to be elevated in Covid-19 patients. The current study aimed to evaluate P-selectin and IL6 in Covid-19 patients with DVT and to explore its relation...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197170/ https://www.ncbi.nlm.nih.gov/pubmed/35712059 http://dx.doi.org/10.2147/IJGM.S357097 |
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author | Farouk, Nehal Ashry, Walaa Mohamed Omar EL-Hagrasy, Hanan A Mohamed, Eman F Eltrawy, Heba H El-Nasser, Asmaa M Shipl, Walaa Attar, Shahinaz El Kh Sakr, Lobna Abdel Wahab, Maisa A Abdelsalam, Eman M Sharaf, Fawzia A Ahmad, Inass Hassan |
author_facet | Farouk, Nehal Ashry, Walaa Mohamed Omar EL-Hagrasy, Hanan A Mohamed, Eman F Eltrawy, Heba H El-Nasser, Asmaa M Shipl, Walaa Attar, Shahinaz El Kh Sakr, Lobna Abdel Wahab, Maisa A Abdelsalam, Eman M Sharaf, Fawzia A Ahmad, Inass Hassan |
author_sort | Farouk, Nehal |
collection | PubMed |
description | BACKGROUND AND AIM: Deep venous thrombosis (DVT) of the lower extremities is common in Covid-19 patients. Interleukin (IL)-6 and P-selectin were found to be elevated in Covid-19 patients. The current study aimed to evaluate P-selectin and IL6 in Covid-19 patients with DVT and to explore its relation to clinical and laboratory parameters in those patients. PATIENTS AND METHODS: The present retrospective study included 150 hospitalized COVID-19 patients diagnosed on the basis of a positive result of reverse-transcriptase polymerase chain reaction (RT-PCR) test. Laboratory assessments were included for IL-6 and P selectin assessments via enzyme-linked immunosorbent assay. The primary outcome of the present study was the development of DVT detected by Doppler ultrasound (DU) evaluation of the lower extremities during the admission. RESULTS: The present study included 150 hospitalized Covid-19 patients. DVT was developed in 59 patients (39.3%). DVP patients had significantly higher levels of P selectin [76.0 (63.0–87.0) versus 63.0 (54.3–75.0), p < 0.001] and IL-6 [37.0 (27.0–49.0) versus 18.5 (13.5–31.5), p < 0.001]. ROC curve analysis revealed good performance of P selectin [AUC (95% CI): 0.72 (0.64–0.81)] and IL-6 [AUC (95% CI): 0.79 (0.71–0.86)] in identification of DVT. Logistic regression analysis identified the presence of severe disease [OR (95% CI): 9.016 (3.61–22.49), p < 0.001], elevated P selectin [OR (95% CI): 1.032 (1.005–1.059), p = 0.018] and elevated IL-6 [OR (95% CI): 1.062 (1.033–1.091), p < 0.001] as significant predictors of DVT development in multivariate analysis. CONCLUSION: The present study identified a probable role of elevated P-selectin and IL-6 levels in the DVT development in hospitalized Covid-19 patients. |
format | Online Article Text |
id | pubmed-9197170 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-91971702022-06-15 Admission Levels of Serum P-Selectin and IL-6 Can Predict Development of Deep Venous Thrombosis in Hospitalized Covid-19 Patients Farouk, Nehal Ashry, Walaa Mohamed Omar EL-Hagrasy, Hanan A Mohamed, Eman F Eltrawy, Heba H El-Nasser, Asmaa M Shipl, Walaa Attar, Shahinaz El Kh Sakr, Lobna Abdel Wahab, Maisa A Abdelsalam, Eman M Sharaf, Fawzia A Ahmad, Inass Hassan Int J Gen Med Original Research BACKGROUND AND AIM: Deep venous thrombosis (DVT) of the lower extremities is common in Covid-19 patients. Interleukin (IL)-6 and P-selectin were found to be elevated in Covid-19 patients. The current study aimed to evaluate P-selectin and IL6 in Covid-19 patients with DVT and to explore its relation to clinical and laboratory parameters in those patients. PATIENTS AND METHODS: The present retrospective study included 150 hospitalized COVID-19 patients diagnosed on the basis of a positive result of reverse-transcriptase polymerase chain reaction (RT-PCR) test. Laboratory assessments were included for IL-6 and P selectin assessments via enzyme-linked immunosorbent assay. The primary outcome of the present study was the development of DVT detected by Doppler ultrasound (DU) evaluation of the lower extremities during the admission. RESULTS: The present study included 150 hospitalized Covid-19 patients. DVT was developed in 59 patients (39.3%). DVP patients had significantly higher levels of P selectin [76.0 (63.0–87.0) versus 63.0 (54.3–75.0), p < 0.001] and IL-6 [37.0 (27.0–49.0) versus 18.5 (13.5–31.5), p < 0.001]. ROC curve analysis revealed good performance of P selectin [AUC (95% CI): 0.72 (0.64–0.81)] and IL-6 [AUC (95% CI): 0.79 (0.71–0.86)] in identification of DVT. Logistic regression analysis identified the presence of severe disease [OR (95% CI): 9.016 (3.61–22.49), p < 0.001], elevated P selectin [OR (95% CI): 1.032 (1.005–1.059), p = 0.018] and elevated IL-6 [OR (95% CI): 1.062 (1.033–1.091), p < 0.001] as significant predictors of DVT development in multivariate analysis. CONCLUSION: The present study identified a probable role of elevated P-selectin and IL-6 levels in the DVT development in hospitalized Covid-19 patients. Dove 2022-06-10 /pmc/articles/PMC9197170/ /pubmed/35712059 http://dx.doi.org/10.2147/IJGM.S357097 Text en © 2022 Farouk et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Farouk, Nehal Ashry, Walaa Mohamed Omar EL-Hagrasy, Hanan A Mohamed, Eman F Eltrawy, Heba H El-Nasser, Asmaa M Shipl, Walaa Attar, Shahinaz El Kh Sakr, Lobna Abdel Wahab, Maisa A Abdelsalam, Eman M Sharaf, Fawzia A Ahmad, Inass Hassan Admission Levels of Serum P-Selectin and IL-6 Can Predict Development of Deep Venous Thrombosis in Hospitalized Covid-19 Patients |
title | Admission Levels of Serum P-Selectin and IL-6 Can Predict Development of Deep Venous Thrombosis in Hospitalized Covid-19 Patients |
title_full | Admission Levels of Serum P-Selectin and IL-6 Can Predict Development of Deep Venous Thrombosis in Hospitalized Covid-19 Patients |
title_fullStr | Admission Levels of Serum P-Selectin and IL-6 Can Predict Development of Deep Venous Thrombosis in Hospitalized Covid-19 Patients |
title_full_unstemmed | Admission Levels of Serum P-Selectin and IL-6 Can Predict Development of Deep Venous Thrombosis in Hospitalized Covid-19 Patients |
title_short | Admission Levels of Serum P-Selectin and IL-6 Can Predict Development of Deep Venous Thrombosis in Hospitalized Covid-19 Patients |
title_sort | admission levels of serum p-selectin and il-6 can predict development of deep venous thrombosis in hospitalized covid-19 patients |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197170/ https://www.ncbi.nlm.nih.gov/pubmed/35712059 http://dx.doi.org/10.2147/IJGM.S357097 |
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