Formononetin Ameliorates Renal Dysfunction, Oxidative Stress, Inflammation, and Apoptosis and Upregulates Nrf2/HO-1 Signaling in a Rat Model of Gentamicin-Induced Nephrotoxicity

Gentamicin (GEN) is a bactericidal aminoglycoside known to cause nephrotoxicity. Formononetin (FN) is a potent flavonoid that exhibits numerous promising pharmacological activities. In this study, we have assessed the nephroprotective efficacy of FN against GEN-induced renal injury in rats. Rats wer...

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Detalles Bibliográficos
Autores principales: Althunibat, Osama Y., Abukhalil, Mohammad H., Aladaileh, Saleem H., Qaralleh, Haitham, Al-Amarat, Wesam, Alfwuaires, Manal A., Algefare, Abdulmohsen I., Namazi, Nader Ibrahim, Melebary, Sahar J., Babalghith, Ahmad O., Conte-Junior, Carlos Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197219/
https://www.ncbi.nlm.nih.gov/pubmed/35712704
http://dx.doi.org/10.3389/fphar.2022.916732

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