Cargando…

A Simple and Robust Single-Step Method for CAR-Vδ1 γδT Cell Expansion and Transduction for Cancer Immunotherapy

The γδT cell subset of peripheral lymphocytes exhibits potent cancer antigen recognition independent of classical peptide MHC complexes, making it an attractive candidate for allogeneic cancer adoptive immunotherapy. The Vδ1-T cell receptor (TCR)-expressing subset of peripheral γδT cells has remaine...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ferry, Gabrielle M., Agbuduwe, Charles, Forrester, Megan, Dunlop, Sophie, Chester, Kerry, Fisher, Jonathan, Anderson, John, Barisa, Marta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197253/ https://www.ncbi.nlm.nih.gov/pubmed/35711450 http://dx.doi.org/10.3389/fimmu.2022.863155

Ejemplares similares

Optimized protocols for γδ T cell expansion and lentiviral transduction
por: Wang, Rui-Ning, et al.
Publicado: (2019)

Interplay between γδT-Cell Metabolism and Tumour Microenvironment Offers Opportunities for Therapeutic Intervention
por: Barisa, Marta, et al.
Publicado: (2021)

Enhancing the effectiveness of γδ T cells by mRNA transfection of chimeric antigen receptors or bispecific T cell engagers
por: Anderson, John, et al.
Publicado: (2023)

Human Vδ2 versus non-Vδ2 γδ T cells in antitumor immunity
por: Kabelitz, Dieter, et al.
Publicado: (2013)

Phenotype and regulation of immunosuppressive Vδ2-expressing γδ T cells
por: Peters, Christian, et al.
Publicado: (2013)

Characterization of Donor Variability for γδ T Cell ex vivo Expansion and Development of an Allogeneic γδ T Cell Immunotherapy
por: Burnham, Rebecca E., et al.
Publicado: (2020)

Suppressive activity of Vδ2(+) γδ T cells on αβ T cells is licensed by TCR signaling and correlates with signal strength
por: Schilbach, Karin, et al.
Publicado: (2020)

Systematic pattern analyses of Vδ2(+) TCRs reveal that shared “public” Vδ2(+) γδ T cell clones are a consequence of rearrangement bias and a higher expansion status
por: Deng, Lihua, et al.
Publicado: (2022)

Hepatocellular carcinoma‐infiltrating γδ T cells are functionally defected and allogenic Vδ2(+) γδ T cell can be a promising complement
por: He, Wenjing, et al.
Publicado: (2022)

Successful adoptive transfer and in vivo expansion of haploidentical γδ T cells
por: Wilhelm, Martin, et al.
Publicado: (2014)

Corrigendum: Systematic pattern analyses of Vδ2(+) TCRs reveal that shared “public” Vδ2(+) γδ T cell clones are a consequence of rearrangement bias and a higher expansion status
por: Deng, Lihua, et al.
Publicado: (2022)

αβ-T cell receptor transduction gives superior mitochondrial function to γδ-T cells with promising persistence
por: Ishihara, Mikiya, et al.
Publicado: (2023)

Structure of the Signal Transduction Domain in Second-Generation CAR Regulates the Input Efficiency of CAR Signals
por: Fujiwara, Kento, et al.
Publicado: (2021)

Higher frequency of circulating Vδ1 γδT cells in patients with advanced schistosomiasis
por: Zheng, Li, et al.
Publicado: (2021)

Distinct phenotype and function of circulating Vδ1(+) and Vδ2(+) γδT-cells in acute and chronic hepatitis B
por: Chang, Kyong-Mi, et al.
Publicado: (2019)

γδ-Enriched CAR-T cell therapy for bone metastatic castrate-resistant prostate cancer
por: Frieling, Jeremy S., et al.
Publicado: (2023)

Co-Expansion of Cytokine-Induced Killer Cells and Vγ9Vδ2 T Cells for CAR T-Cell Therapy
por: Du, Shou-Hui, et al.
Publicado: (2016)

Integral Roles for Integrins in γδ T Cell Function
por: Siegers, Gabrielle M.
Publicado: (2018)

Inversion of the Vδ1 to Vδ2 γδ T cell ratio in CVID is not restored by IVIg and is associated with immune activation and exhaustion
por: Paquin-Proulx, Dominic, et al.
Publicado: (2016)

Role of Vγ9Vδ2+ γδ T cells in juvenile idiopathic arthritis
por: Gerstein, M, et al.
Publicado: (2008)

Flow Cytometric Pattern of TCRVδ Subtype Expression Rapidly Identifies γδT Cell Lymphoma
por: Chen, Xiao, et al.
Publicado: (2020)

A simple and robust clinical manufacturing process for the ex-vivo expansion of autologous T cells genetically engineered to express an anti-BCMA chimeric antigen receptor (CAR) for the treatment of multiple myeloma
por: Ladd, Alden, et al.
Publicado: (2015)

BiTE‐Secreting CAR‐γδT as a Dual Targeting Strategy for the Treatment of Solid Tumors
por: Huang, Shi‐Wei, et al.
Publicado: (2023)

Expansion of human γδ T cells for adoptive immunotherapy using a bisphosphonate prodrug
por: Tanaka, Yoshimasa, et al.
Publicado: (2018)

Establishment of a simple and efficient platform for car-t cell generation and expansion: from lentiviral production to in vivo studies
por: Picanço-Castro, Virgínia, et al.
Publicado: (2020)

Different composition of the human and the mouse γδ T cell receptor explains different phenotypes of CD3γ and CD3δ immunodeficiencies
por: Siegers, Gabrielle M., et al.
Publicado: (2007)

Different composition of the human and the mouse γδ T cell receptor explains different phenotypes of CD3γ and CD3δ immunodeficiencies
por: Siegers, Gabrielle M., et al.
Publicado: (2007)

CD81 costimulation skews CAR transduction toward naive T cells
por: Schultz, Liora M., et al.
Publicado: (2022)

Antigen recognition by human γδ T cells: one step closer to knowing
por: Eberl, Matthias
Publicado: (2020)

Inversion of the Vδ1 to Vδ2 γδ T cell ratio in CVID is not restored by IVIg and is associated with immune activation and exhaustion: Erratum
Publicado: (2017)

CMV-Independent Lysis of Glioblastoma by Ex Vivo Expanded/Activated Vδ1+ γδ T Cells
por: Knight, Andrea, et al.
Publicado: (2013)

Human Peripheral CD4(+) Vδ1(+) γδT Cells Can Develop into αβT Cells
por: Ziegler, Hendrik, et al.
Publicado: (2014)

Potential Role of Vδ2(+) γδ T Cells in Regulation of Immune Activation in Primary HIV Infection
por: Bhatnagar, Nupur, et al.
Publicado: (2017)

Exhausted intratumoral Vδ2(−) γδ T cells in human kidney cancer retain effector function
por: Rancan, Chiara, et al.
Publicado: (2023)

Metformin Promotes the Protection of Mice Infected With Plasmodium yoelii Independently of γδ T Cell Expansion
por: Miyakoda, Mana, et al.
Publicado: (2018)

Enriching leukapheresis improves T cell activation and transduction efficiency during CAR T processing
por: Noaks, Elsa, et al.
Publicado: (2021)

The expansion of targetable biomarkers for CAR T cell therapy
por: Townsend, Michelle H., et al.
Publicado: (2018)

Efficient Transduction and Expansion of Ovine Macrophages for Gene Therapy Implementations
por: Karponi, Garyfalia, et al.
Publicado: (2018)

Essential and Partially Overlapping Role of CD3γ and CD3δ for Development of αβ and γδ T Lymphocytes
por: Wang, Baoping, et al.
Publicado: (1998)

Genetic Influence on the Peripheral Differentiation Signature of Vδ2+ γδ and CD4+ αβ T Cells in Adults
por: Beucke, Nicola, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_6b3rdujvum1lkhbuk60av9r48i