Alzheimer’s disease associated AKAP9 I2558M mutation alters posttranslational modification and interactome of tau and cellular functions in CRISPR‐edited human neuronal cells

Alzheimer's disease (AD) is a pervasive neurodegeneration disease with high heritability. In this study, we employed CRISPR‐Cas9‐engineered technology to investigate the effects of a rare mutation (rs144662445) in the A kinase anchoring protein 9 (AKAP9) gene, which is associated with AD in Afr...

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Detalles Bibliográficos
Autores principales: You, Yang, Hersh, Samuel W., Aslebagh, Roshanak, Shaffer, Scott A., Ikezu, Seiko, Mez, Jesse, Lunetta, Kathryn L., Logue, Mark W., Farrer, Lindsay A., Ikezu, Tsuneya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197405/
https://www.ncbi.nlm.nih.gov/pubmed/35567427
http://dx.doi.org/10.1111/acel.13617

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197405/
https://www.ncbi.nlm.nih.gov/pubmed/35567427
http://dx.doi.org/10.1111/acel.13617

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