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Central tolerance is impaired in the middle‐aged thymic environment
One of the earliest hallmarks of immune aging is thymus involution, which not only reduces the number of newly generated and exported T cells, but also alters the composition and organization of the thymus microenvironment. Thymic T‐cell export continues into adulthood, yet the impact of thymus invo...
Autores principales: | Lancaster, Jessica N., Keatinge‐Clay, Damaris E., Srinivasan, Jayashree, Li, Yu, Selden, Hilary J., Nam, Seohee, Richie, Ellen R., Ehrlich, Lauren I. R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197411/ https://www.ncbi.nlm.nih.gov/pubmed/35561351 http://dx.doi.org/10.1111/acel.13624 |
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