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Abnormal Insular Dynamic Functional Connectivity and Its Relation to Social Dysfunctioning in Children With Attention Deficit/Hyperactivity Disorder

Anomalies in large-scale cognitive control networks impacting social attention abilities are hypothesized to be the cause of attention deficit hyperactivity disorder (ADHD). The precise nature of abnormal brain functional connectivity (FC) dynamics including other regions, on the other hand, is unkn...

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Autores principales: Fateh, Ahmed Ameen, Huang, Wenxian, Mo, Tong, Wang, Xiaoyu, Luo, Yi, Yang, Binrang, Smahi, Abla, Fang, Diangang, Zhang, Linlin, Meng, Xianlei, Zeng, Hongwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197452/
https://www.ncbi.nlm.nih.gov/pubmed/35712452
http://dx.doi.org/10.3389/fnins.2022.890596
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author Fateh, Ahmed Ameen
Huang, Wenxian
Mo, Tong
Wang, Xiaoyu
Luo, Yi
Yang, Binrang
Smahi, Abla
Fang, Diangang
Zhang, Linlin
Meng, Xianlei
Zeng, Hongwu
author_facet Fateh, Ahmed Ameen
Huang, Wenxian
Mo, Tong
Wang, Xiaoyu
Luo, Yi
Yang, Binrang
Smahi, Abla
Fang, Diangang
Zhang, Linlin
Meng, Xianlei
Zeng, Hongwu
author_sort Fateh, Ahmed Ameen
collection PubMed
description Anomalies in large-scale cognitive control networks impacting social attention abilities are hypothesized to be the cause of attention deficit hyperactivity disorder (ADHD). The precise nature of abnormal brain functional connectivity (FC) dynamics including other regions, on the other hand, is unknown. The concept that insular dynamic FC (dFC) among distinct brain regions is dysregulated in children with ADHD was evaluated using Insular subregions, and we studied how these dysregulations lead to social dysfunctioning. Data from 30 children with ADHD and 28 healthy controls (HCs) were evaluated using dynamic resting state functional magnetic resonance imaging (rs-fMRI). We evaluated the dFC within six subdivisions, namely both left and right dorsal anterior insula (dAI), ventral anterior insula (vAI), and posterior insula (PI). Using the insular sub-regions as seeds, we performed group comparison between the two groups. To do so, two sample t-tests were used, followed by post-hoc t-tests. Compared to the HCs, patients with ADHD exhibited decreased dFC values between right dAI and the left middle frontal gyrus, left postcentral gyrus and right of cerebellum crus, respectively. Results also showed a decreased dFC between left dAI and thalamus, left vAI and left precuneus and left PI with temporal pole. From the standpoint of the dynamic functional connectivity of insular subregions, our findings add to the growing body of evidence on brain dysfunction in ADHD. This research adds to our understanding of the neurocognitive mechanisms behind social functioning deficits in ADHD. Future ADHD research could benefit from merging the dFC approach with task-related fMRI and non-invasive brain stimulation, which could aid in the diagnosis and treatment of the disorder.
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spelling pubmed-91974522022-06-15 Abnormal Insular Dynamic Functional Connectivity and Its Relation to Social Dysfunctioning in Children With Attention Deficit/Hyperactivity Disorder Fateh, Ahmed Ameen Huang, Wenxian Mo, Tong Wang, Xiaoyu Luo, Yi Yang, Binrang Smahi, Abla Fang, Diangang Zhang, Linlin Meng, Xianlei Zeng, Hongwu Front Neurosci Neuroscience Anomalies in large-scale cognitive control networks impacting social attention abilities are hypothesized to be the cause of attention deficit hyperactivity disorder (ADHD). The precise nature of abnormal brain functional connectivity (FC) dynamics including other regions, on the other hand, is unknown. The concept that insular dynamic FC (dFC) among distinct brain regions is dysregulated in children with ADHD was evaluated using Insular subregions, and we studied how these dysregulations lead to social dysfunctioning. Data from 30 children with ADHD and 28 healthy controls (HCs) were evaluated using dynamic resting state functional magnetic resonance imaging (rs-fMRI). We evaluated the dFC within six subdivisions, namely both left and right dorsal anterior insula (dAI), ventral anterior insula (vAI), and posterior insula (PI). Using the insular sub-regions as seeds, we performed group comparison between the two groups. To do so, two sample t-tests were used, followed by post-hoc t-tests. Compared to the HCs, patients with ADHD exhibited decreased dFC values between right dAI and the left middle frontal gyrus, left postcentral gyrus and right of cerebellum crus, respectively. Results also showed a decreased dFC between left dAI and thalamus, left vAI and left precuneus and left PI with temporal pole. From the standpoint of the dynamic functional connectivity of insular subregions, our findings add to the growing body of evidence on brain dysfunction in ADHD. This research adds to our understanding of the neurocognitive mechanisms behind social functioning deficits in ADHD. Future ADHD research could benefit from merging the dFC approach with task-related fMRI and non-invasive brain stimulation, which could aid in the diagnosis and treatment of the disorder. Frontiers Media S.A. 2022-05-31 /pmc/articles/PMC9197452/ /pubmed/35712452 http://dx.doi.org/10.3389/fnins.2022.890596 Text en Copyright © 2022 Fateh, Huang, Mo, Wang, Luo, Yang, Smahi, Fang, Zhang, Meng and Zeng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Fateh, Ahmed Ameen
Huang, Wenxian
Mo, Tong
Wang, Xiaoyu
Luo, Yi
Yang, Binrang
Smahi, Abla
Fang, Diangang
Zhang, Linlin
Meng, Xianlei
Zeng, Hongwu
Abnormal Insular Dynamic Functional Connectivity and Its Relation to Social Dysfunctioning in Children With Attention Deficit/Hyperactivity Disorder
title Abnormal Insular Dynamic Functional Connectivity and Its Relation to Social Dysfunctioning in Children With Attention Deficit/Hyperactivity Disorder
title_full Abnormal Insular Dynamic Functional Connectivity and Its Relation to Social Dysfunctioning in Children With Attention Deficit/Hyperactivity Disorder
title_fullStr Abnormal Insular Dynamic Functional Connectivity and Its Relation to Social Dysfunctioning in Children With Attention Deficit/Hyperactivity Disorder
title_full_unstemmed Abnormal Insular Dynamic Functional Connectivity and Its Relation to Social Dysfunctioning in Children With Attention Deficit/Hyperactivity Disorder
title_short Abnormal Insular Dynamic Functional Connectivity and Its Relation to Social Dysfunctioning in Children With Attention Deficit/Hyperactivity Disorder
title_sort abnormal insular dynamic functional connectivity and its relation to social dysfunctioning in children with attention deficit/hyperactivity disorder
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197452/
https://www.ncbi.nlm.nih.gov/pubmed/35712452
http://dx.doi.org/10.3389/fnins.2022.890596
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