A p300/GATA6 axis determines differentiation and Wnt dependency in pancreatic cancer models

Wnt signaling regulates the balance between stemness and differentiation in multiple tissues and in cancer. RNF43-mutant pancreatic cancers are dependent on Wnt production, and pharmacologic blockade of the pathway, e.g., by PORCN inhibitors, leads to tumor differentiation. However, primary resistan...

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Detalles Bibliográficos
Autores principales: Zhong, Zheng, Harmston, Nathan, Wood, Kris C., Madan, Babita, Virshup, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197518/
https://www.ncbi.nlm.nih.gov/pubmed/35536676
http://dx.doi.org/10.1172/JCI156305

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197518/
https://www.ncbi.nlm.nih.gov/pubmed/35536676
http://dx.doi.org/10.1172/JCI156305

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