FOXA2 suppresses endometrial carcinogenesis and epithelial-mesenchymal transition by regulating enhancer activity

FOXA2 encodes a transcription factor mutated in 10% of endometrial cancers (ECs), with a higher mutation rate in aggressive variants. FOXA2 has essential roles in embryonic and uterine development. However, FOXA2’s role in EC is incompletely understood. Functional investigations using human and mous...

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Detalles Bibliográficos
Autores principales: Sahoo, Subhransu S., Ramanand, Susmita G., Gao, Yunpeng, Abbas, Ahmed, Kumar, Ashwani, Cuevas, Ileana C., Li, Hao-Dong, Aguilar, Mitzi, Xing, Chao, Mani, Ram S., Castrillon, Diego H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197528/
https://www.ncbi.nlm.nih.gov/pubmed/35703180
http://dx.doi.org/10.1172/JCI157574

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197528/
https://www.ncbi.nlm.nih.gov/pubmed/35703180
http://dx.doi.org/10.1172/JCI157574

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