Cargando…

FOXA2 suppresses endometrial carcinogenesis and epithelial-mesenchymal transition by regulating enhancer activity

FOXA2 encodes a transcription factor mutated in 10% of endometrial cancers (ECs), with a higher mutation rate in aggressive variants. FOXA2 has essential roles in embryonic and uterine development. However, FOXA2’s role in EC is incompletely understood. Functional investigations using human and mous...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sahoo, Subhransu S., Ramanand, Susmita G., Gao, Yunpeng, Abbas, Ahmed, Kumar, Ashwani, Cuevas, Ileana C., Li, Hao-Dong, Aguilar, Mitzi, Xing, Chao, Mani, Ram S., Castrillon, Diego H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197528/ https://www.ncbi.nlm.nih.gov/pubmed/35703180 http://dx.doi.org/10.1172/JCI157574

Ejemplares similares

Fbxw7 is a driver of uterine carcinosarcoma by promoting epithelial-mesenchymal transition
por: Cuevas, Ileana C., et al.
Publicado: (2019)

Endometrial polyps are non-neoplastic but harbor epithelial mutations in endometrial cancer drivers at low allelic frequencies
por: Sahoo, Subhransu S., et al.
Publicado: (2022)

Reliable Identification of Endometrial Precancers Through Combined Pax2, β-Catenin, and Pten Immunohistochemistry
por: Aguilar, Mitzi, et al.
Publicado: (2022)

Serial genomic analysis of endometrium supports the existence of histologically indistinct endometrial cancer precursors
por: Aguilar, Mitzi, et al.
Publicado: (2021)

β-catenin, Pax2, and Pten Panel Identifies Precancers Among Histologically Subdiagnostic Endometrial Lesions
por: Aguilar, Mitzi, et al.
Publicado: (2023)

Epithelial to Mesenchymal Transition and Cell Biology of Molecular Regulation in Endometrial Carcinogenesis
por: Chiu, Hsiao-Chen, et al.
Publicado: (2019)

VEGF-mTOR signaling links obesity and endometrial cancer
por: Sahoo, Subhransu S., et al.
Publicado: (2018)

Pioneer Factors FOXA1 and FOXA2 Assist Selective Glucocorticoid Receptor Signaling in Human Endometrial Cells
por: Whirledge, Shannon, et al.
Publicado: (2017)

FOXA2 promotes the proliferation, migration and invasion, and epithelial mesenchymal transition in colon cancer
por: Wang, Baolei, et al.
Publicado: (2018)

The Emerging Role of the Microenvironment in Endometrial Cancer
por: Sahoo, Subhransu S., et al.
Publicado: (2018)

Switch in FOXA1 Status Associates with Endometrial Cancer Progression
por: Tangen, Ingvild Løberg, et al.
Publicado: (2014)

IGF-1 and hyperglycaemia-induced FOXA1 and IGFBP-2 affect epithelial to mesenchymal transition in prostate epithelial cells
por: Mansor, Rehanna, et al.
Publicado: (2020)

Foxa1 and Foxa2 in thymic epithelial cells (TEC) regulate medullary TEC and regulatory T-cell maturation
por: Lau, Ching-In, et al.
Publicado: (2018)

Correction: IGF-1 and hyperglycaemia-induced FOXA1 and IGFBP-2 affect epithelial to mesenchymal transition in prostate epithelial cells
por: Mansor, Rehanna, et al.
Publicado: (2023)

The Role of Carcinogenesis-Related Biomarkers in the Wnt Pathway and Their Effects on Epithelial–Mesenchymal Transition (EMT) in Oral Squamous Cell Carcinoma
por: Bai, Yunpeng, et al.
Publicado: (2020)

The Molecular Mechanism of Epithelial–Mesenchymal Transition for Breast Carcinogenesis
por: Li, Chia-Jung, et al.
Publicado: (2019)

Foxa1 and Foxa2 Are Required for Formation of the Intervertebral Discs
por: Maier, Jennifer A., et al.
Publicado: (2013)

Significance of the NOR1-FOXA1/HDAC2-Slug regulatory network in epithelial-mesenchymal transition of tumor cells
por: Wang, Wei, et al.
Publicado: (2016)

PGC1α Cooperates with FOXA1 to Regulate Epithelial Mesenchymal Transition through the TCF4-TWIST1
por: Fang, Xue-Quan, et al.
Publicado: (2022)

A systematic approach identifies FOXA1 as a key factor in the loss of epithelial traits during the epithelial-to-mesenchymal transition in lung cancer
por: Wang, Haiyun, et al.
Publicado: (2013)

Cooperation between p53 and the telomere-protecting shelterin component Pot1a in endometrial carcinogenesis
por: Akbay, E A, et al.
Publicado: (2013)

Control of Oocyte Reawakening by Kit
por: Saatcioglu, Hatice Duygu, et al.
Publicado: (2016)

Immunosuppressive Traits of the Hybrid Epithelial/Mesenchymal Phenotype
por: Sahoo, Sarthak, et al.
Publicado: (2021)

Hypoxia and Angiogenesis in Endometrioid Endometrial Carcinogenesis
por: Horrée, Nicole, et al.
Publicado: (2007)

Effects of Tamoxifen on Endometrial Carcinogenesis in Mice
por: Niwa, Kenji, et al.
Publicado: (1998)

Gene Promoter Methylation in Endometrial Carcinogenesis
por: Cornel, Karlijn M. C., et al.
Publicado: (2018)

Spectroscopic evaluation of carcinogenesis in endometrial cancer
por: Depciuch, Joanna, et al.
Publicado: (2021)

Phosphorylation and Reorganization of Keratin Networks: Implications for Carcinogenesis and Epithelial Mesenchymal Transition
por: Kim, Hyun Ji, et al.
Publicado: (2015)

Immunological Aspects of the Tumor Microenvironment and Epithelial-Mesenchymal Transition in Gastric Carcinogenesis
por: Baj, Jacek, et al.
Publicado: (2020)

FoxA2 hunting research identifies the early trail of mesenchymal differentiation
por: Madeddu, Paolo
Publicado: (2013)

Epithelial Transcription Factor FOXA1 Regulates Prostate Cancer Immune Response
por: Brea, Lourdes T, et al.
Publicado: (2021)

FOXA1 can be modulated by HDAC3 in the progression of epithelial ovarian carcinoma
por: Lou, Tong, et al.
Publicado: (2022)

FOXA1 promotes tumor cell proliferation through AR involving the Notch pathway in endometrial cancer
por: Qiu, Meiting, et al.
Publicado: (2014)

Progesterone Inhibits Epithelial-to-Mesenchymal Transition in Endometrial Cancer
por: van der Horst, Paul H., et al.
Publicado: (2012)

FGFR-2 and Epithelial–Mesenchymal Transition in Endometrial Cancer
por: Adamczyk-Gruszka, Olga, et al.
Publicado: (2022)

Transcription factors Foxa1 and Foxa2 are required for adult dopamine neurons maintenance
por: Domanskyi, Andrii, et al.
Publicado: (2014)

Opposing Roles of FoxA1 and FoxA3 in Intrahepatic Cholangiocarcinoma Progression
por: Thanan, Raynoo, et al.
Publicado: (2020)

A re-appraisal of mesenchymal-epithelial transition (MET) in endometrial epithelial remodeling
por: Spooner-Harris, Madelyn, et al.
Publicado: (2022)

Hypermethylation of SOX2 Promoter in Endometrial Carcinogenesis
por: Wong, Oscar Gee-Wan, et al.
Publicado: (2010)

Revisiting Epithelial Carcinogenesis
por: Méndez-López, Luis Fernando
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_0s89jrav4a5c20bcf6j3i431jl