CAR T cell manufacturing from naive/stem memory T lymphocytes enhances antitumor responses while curtailing cytokine release syndrome

Chimeric antigen receptor (CAR) T cell expansion and persistence represent key factors to achieve complete responses and prevent relapses. These features are typical of early memory T cells, which can be highly enriched through optimized manufacturing protocols. Here, we investigated the efficacy an...

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Detalles Bibliográficos
Autores principales: Arcangeli, Silvia, Bove, Camilla, Mezzanotte, Claudia, Camisa, Barbara, Falcone, Laura, Manfredi, Francesco, Bezzecchi, Eugenia, El Khoury, Rita, Norata, Rossana, Sanvito, Francesca, Ponzoni, Maurilio, Greco, Beatrice, Moresco, Marta Angiola, Carrabba, Matteo G., Ciceri, Fabio, Bonini, Chiara, Bondanza, Attilio, Casucci, Monica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197529/
https://www.ncbi.nlm.nih.gov/pubmed/35503659
http://dx.doi.org/10.1172/JCI150807

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