Novel Targeting of DNA Methyltransferase Activity Inhibits Ewing Sarcoma Cell Proliferation and Enhances Tumor Cell Sensitivity to DNA Damaging Drugs by Activating the DNA Damage Response

DNA methylation is an important component of the epigenetic machinery that regulates the malignancy of Ewing sarcoma (EWS), the second most common primary bone tumor in children and adolescents. Coordination of DNA methylation and DNA replication is critical for maintaining epigenetic programming an...

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Detalles Bibliográficos
Autores principales: Cristalli, Camilla, Manara, Maria Cristina, Valente, Sergio, Pellegrini, Evelin, Bavelloni, Alberto, De Feo, Alessandra, Blalock, William, Di Bello, Elisabetta, Piñeyro, David, Merkel, Angelika, Esteller, Manel, Tirado, Oscar M., Mai, Antonello, Scotlandi, Katia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197596/
https://www.ncbi.nlm.nih.gov/pubmed/35712255
http://dx.doi.org/10.3389/fendo.2022.876602

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