Application of Tivantinib for Hepatocellular Carcinoma: A Meta-Analysis Study

OBJECTIVES: The efficacy of tivantinib may have some potential in treating MET-high hepatocellular carcinoma, and we aim to compare tivantinib with placebo for the treatment of MET-high hepatocellular carcinoma. METHODS: Several databases including PubMed, Cochrane Library, Web of Science, EBSCO, an...

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Detalles Bibliográficos
Autores principales: Luo, Guang-li, Guo, Bian-qin, Wu, Li-xiang, Shen, Yan-xi, Xie, Tingting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197645/
https://www.ncbi.nlm.nih.gov/pubmed/35711496
http://dx.doi.org/10.1155/2022/1976788
Descripción
Sumario:OBJECTIVES: The efficacy of tivantinib may have some potential in treating MET-high hepatocellular carcinoma, and we aim to compare tivantinib with placebo for the treatment of MET-high hepatocellular carcinoma. METHODS: Several databases including PubMed, Cochrane Library, Web of Science, EBSCO, and EMbase have been systematically searched through March 2022, and we included studies regarding the treatment of MET-high hepatocellular carcinoma by using tivantinib versus placebo. RESULTS: We finally include three RCTs. In comparison with placebo for MET-high hepatocellular carcinoma, tivantinib reveals no significant influence on overall survival (P=0.21), progression-free survival (P=0.13), time to progression (P=0.38), or grade ≥3 anemia (P=0.50) but increases the incidence of grade ≥3 neutropenia (P=0.04). CONCLUSIONS: Tivantinib may provide no additional benefits for MET-high hepatocellular carcinoma.

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