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Diet, Microbes, and Cancer Across the Tree of Life: a Systematic Review

PURPOSE OF REVIEW: Cancers are a leading cause of death in humans and for many other species. Diet has often been associated with cancers, and the microbiome is an essential mediator between diet and cancers. Here, we review the work on cancer and the microbiome across species to search for broad pa...

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Autores principales: Kapsetaki, Stefania E., Marquez Alcaraz, Gissel, Maley, Carlo C., Whisner, Corrie M., Aktipis, Athena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197725/
https://www.ncbi.nlm.nih.gov/pubmed/35704266
http://dx.doi.org/10.1007/s13668-022-00420-5
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author Kapsetaki, Stefania E.
Marquez Alcaraz, Gissel
Maley, Carlo C.
Whisner, Corrie M.
Aktipis, Athena
author_facet Kapsetaki, Stefania E.
Marquez Alcaraz, Gissel
Maley, Carlo C.
Whisner, Corrie M.
Aktipis, Athena
author_sort Kapsetaki, Stefania E.
collection PubMed
description PURPOSE OF REVIEW: Cancers are a leading cause of death in humans and for many other species. Diet has often been associated with cancers, and the microbiome is an essential mediator between diet and cancers. Here, we review the work on cancer and the microbiome across species to search for broad patterns of susceptibility associated with different microbial species. RECENT FINDINGS: Some microbes, such as Helicobacter bacteria, papillomaviruses, and the carnivore-associated Fusobacteria, consistently induce tumorigenesis in humans and other species. Other microbes, such as the milk-associated Lactobacillus, consistently inhibit tumorigenesis in humans and other species. SUMMARY: We systematically reviewed over a thousand published articles and identified links between diet, microbes, and cancers in several species of mammals, birds, and flies. Future work should examine a larger variety of host species to discover new model organisms for human preclinical trials, to better understand the observed variance in cancer prevalence across species, and to discover which microbes and diets are associated with cancers across species. Ultimately, this could help identify microbial and dietary interventions to diagnose, prevent, and treat cancers in humans as well as other animals. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13668-022-00420-5.
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spelling pubmed-91977252022-06-17 Diet, Microbes, and Cancer Across the Tree of Life: a Systematic Review Kapsetaki, Stefania E. Marquez Alcaraz, Gissel Maley, Carlo C. Whisner, Corrie M. Aktipis, Athena Curr Nutr Rep Cancer (RA Murphy, Section Editor) PURPOSE OF REVIEW: Cancers are a leading cause of death in humans and for many other species. Diet has often been associated with cancers, and the microbiome is an essential mediator between diet and cancers. Here, we review the work on cancer and the microbiome across species to search for broad patterns of susceptibility associated with different microbial species. RECENT FINDINGS: Some microbes, such as Helicobacter bacteria, papillomaviruses, and the carnivore-associated Fusobacteria, consistently induce tumorigenesis in humans and other species. Other microbes, such as the milk-associated Lactobacillus, consistently inhibit tumorigenesis in humans and other species. SUMMARY: We systematically reviewed over a thousand published articles and identified links between diet, microbes, and cancers in several species of mammals, birds, and flies. Future work should examine a larger variety of host species to discover new model organisms for human preclinical trials, to better understand the observed variance in cancer prevalence across species, and to discover which microbes and diets are associated with cancers across species. Ultimately, this could help identify microbial and dietary interventions to diagnose, prevent, and treat cancers in humans as well as other animals. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13668-022-00420-5. Springer US 2022-06-15 2022 /pmc/articles/PMC9197725/ /pubmed/35704266 http://dx.doi.org/10.1007/s13668-022-00420-5 Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Cancer (RA Murphy, Section Editor)
Kapsetaki, Stefania E.
Marquez Alcaraz, Gissel
Maley, Carlo C.
Whisner, Corrie M.
Aktipis, Athena
Diet, Microbes, and Cancer Across the Tree of Life: a Systematic Review
title Diet, Microbes, and Cancer Across the Tree of Life: a Systematic Review
title_full Diet, Microbes, and Cancer Across the Tree of Life: a Systematic Review
title_fullStr Diet, Microbes, and Cancer Across the Tree of Life: a Systematic Review
title_full_unstemmed Diet, Microbes, and Cancer Across the Tree of Life: a Systematic Review
title_short Diet, Microbes, and Cancer Across the Tree of Life: a Systematic Review
title_sort diet, microbes, and cancer across the tree of life: a systematic review
topic Cancer (RA Murphy, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197725/
https://www.ncbi.nlm.nih.gov/pubmed/35704266
http://dx.doi.org/10.1007/s13668-022-00420-5
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