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Brain functional connectivity in children with developmental coordination disorder following rehabilitation intervention

BACKGROUND: Children with developmental coordination disorder (DCD) show improved motor function after Cognitive Orientation to Occupational Performance (CO-OP) intervention; however, the neural basis for these improvements is unknown. METHODS: In this randomized waitlist-controlled trial, 78 childr...

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Autores principales: Izadi-Najafabadi, Sara, Rinat, Shie, Zwicker, Jill G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197764/
https://www.ncbi.nlm.nih.gov/pubmed/33934120
http://dx.doi.org/10.1038/s41390-021-01517-3
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author Izadi-Najafabadi, Sara
Rinat, Shie
Zwicker, Jill G.
author_facet Izadi-Najafabadi, Sara
Rinat, Shie
Zwicker, Jill G.
author_sort Izadi-Najafabadi, Sara
collection PubMed
description BACKGROUND: Children with developmental coordination disorder (DCD) show improved motor function after Cognitive Orientation to Occupational Performance (CO-OP) intervention; however, the neural basis for these improvements is unknown. METHODS: In this randomized waitlist-controlled trial, 78 children with DCD (with/without ADHD) were randomly assigned to either a treatment or waitlist group and underwent three resting-state MRI scans over six months. The treatment group received intervention between the first and second scan; the waitlist group received intervention between the second and third scan. RESULTS: After CO-OP intervention, children with DCD [13 male, 8 female; mean (SD) age: 10.0 (1.7) years] showed increased functional connectivity between the default mode network and right anterior cingulate gyrus (p < 0.01). Additional gains were noted at follow-up three months after the intervention, with greater functional connectivity between the dorsal attention network and precentral gyrus (p < 0.02). However, children with DCD + ADHD [18 male, 1 female; mean (SD) age: 10.0 (1.14) years] did not show brain changes following CO-OP. CONCLUSION: For children with DCD, increased functional connectivity in networks associated with self-, emotion-, and attention-regulation may underlie motor skill improvements observed after CO-OP intervention. Modifications to the CO-OP protocol may be required to induce similar brain changes in children with DCD + ADHD. IMPACT: This study provides neuroscientific evidence for the Cognitive Orientation to Occupational Performance (CO-OP) approach as an effective rehabilitation intervention to induce brain and behavioral changes in children with DCD. While children with DCD ± ADHD showed improved motor function after CO-OP, only children with DCD showed brain changes after intervention. Children with DCD showed increased functional connectivity in networks associated with self-, emotion-, and attention-regulation after the intervention. Treatment modifications may be required to induce similar brain changes in children with DCD + ADHD. Pediatricians are encouraged to refer children with DCD  with and without ADHD for CO-OP intervention to improve their motor skills.
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spelling pubmed-91977642022-06-16 Brain functional connectivity in children with developmental coordination disorder following rehabilitation intervention Izadi-Najafabadi, Sara Rinat, Shie Zwicker, Jill G. Pediatr Res Clinical Research Article BACKGROUND: Children with developmental coordination disorder (DCD) show improved motor function after Cognitive Orientation to Occupational Performance (CO-OP) intervention; however, the neural basis for these improvements is unknown. METHODS: In this randomized waitlist-controlled trial, 78 children with DCD (with/without ADHD) were randomly assigned to either a treatment or waitlist group and underwent three resting-state MRI scans over six months. The treatment group received intervention between the first and second scan; the waitlist group received intervention between the second and third scan. RESULTS: After CO-OP intervention, children with DCD [13 male, 8 female; mean (SD) age: 10.0 (1.7) years] showed increased functional connectivity between the default mode network and right anterior cingulate gyrus (p < 0.01). Additional gains were noted at follow-up three months after the intervention, with greater functional connectivity between the dorsal attention network and precentral gyrus (p < 0.02). However, children with DCD + ADHD [18 male, 1 female; mean (SD) age: 10.0 (1.14) years] did not show brain changes following CO-OP. CONCLUSION: For children with DCD, increased functional connectivity in networks associated with self-, emotion-, and attention-regulation may underlie motor skill improvements observed after CO-OP intervention. Modifications to the CO-OP protocol may be required to induce similar brain changes in children with DCD + ADHD. IMPACT: This study provides neuroscientific evidence for the Cognitive Orientation to Occupational Performance (CO-OP) approach as an effective rehabilitation intervention to induce brain and behavioral changes in children with DCD. While children with DCD ± ADHD showed improved motor function after CO-OP, only children with DCD showed brain changes after intervention. Children with DCD showed increased functional connectivity in networks associated with self-, emotion-, and attention-regulation after the intervention. Treatment modifications may be required to induce similar brain changes in children with DCD + ADHD. Pediatricians are encouraged to refer children with DCD  with and without ADHD for CO-OP intervention to improve their motor skills. Nature Publishing Group US 2021-05-01 2022 /pmc/articles/PMC9197764/ /pubmed/33934120 http://dx.doi.org/10.1038/s41390-021-01517-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Clinical Research Article
Izadi-Najafabadi, Sara
Rinat, Shie
Zwicker, Jill G.
Brain functional connectivity in children with developmental coordination disorder following rehabilitation intervention
title Brain functional connectivity in children with developmental coordination disorder following rehabilitation intervention
title_full Brain functional connectivity in children with developmental coordination disorder following rehabilitation intervention
title_fullStr Brain functional connectivity in children with developmental coordination disorder following rehabilitation intervention
title_full_unstemmed Brain functional connectivity in children with developmental coordination disorder following rehabilitation intervention
title_short Brain functional connectivity in children with developmental coordination disorder following rehabilitation intervention
title_sort brain functional connectivity in children with developmental coordination disorder following rehabilitation intervention
topic Clinical Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197764/
https://www.ncbi.nlm.nih.gov/pubmed/33934120
http://dx.doi.org/10.1038/s41390-021-01517-3
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